What Is Pink Cocaine? The Dark Reality behind a Colorful Name

IF 6.8 1区 医学 Q1 CHEMISTRY, MEDICINAL Journal of Medicinal Chemistry Pub Date : 2024-12-03 DOI:10.1021/acs.jmedchem.4c02821
Lisa Barbaro, Jacob L. Bouchard
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It has been circulating in Colombia, where it is more commonly known as “tusi” or “tusibi”, since the late 2000s, with the earliest reports dating back to 2012. (3) The nicknames “tusibi” and the shortened “tusi” derive from a phonetic translation of “2C-B”, a hallucinogenic phenethylamine first synthesized by Alexander Shulgin in 1974. (4) Known to induce euphoria and hallucinations reportedly similar to a blend of MDMA and LSD, 2C-B belongs to the broader “2C-X family” of drugs (psychedelic phenethylamines containing 2,5-dimethoxy substitution) and was widely popular in the European rave and party scenes in the 1990s. In the late 2000s, 2C-B surfaced in Colombia’s vibrant nightlife, where its reputation as a “designer” drug began to solidify. The signature pink hue was introduced as a way to mask the unpleasant and harsh taste of 2C-B when consumed, the food coloring and aromatic additives transforming the drug into a visually enticing and instantly recognizable powder. The drug’s evolution to the pink cocaine product of today was driven by the surge in demand for 2C-B in the Colombian market. As supply chains struggled to keep up, dealers began cutting 2C-B with more accessible and cheaper psychoactive substances to mimic its stimulant and hallucinogenic effects. (5) Eventually, 2C-B disappeared from the formulation altogether, giving way to the current iterations of pink cocaine. Recently, law enforcement agencies and drug-checking services have reported an uptick in pink cocaine’s presence beyond Latin America, particularly in Europe and North America. (6,7) In the United States, pink cocaine has slowly gained popularity within the club scenes in New York, Miami, and Los Angeles. In 2023, multiple large-scale seizures in the U.S. further underscored its growing popularity. The primary danger of pink cocaine lies in the unknown. Not only is the name itself misleading, giving the illusion of a stimulant akin to cocaine, but the user is completely unaware of the cocktail of substances hidden beneath its appealing pink shade. Aside from the pink food coloring, little about this drug is consistent. Each batch varies widely in composition and potency, exposing users to a risky blend of substances with unpredictable polypharmacology and drug–drug interactions. While the exact amounts and ratios of its ingredients are uncertain, drug-checking studies across the globe have frequently revealed ketamine and MDMA as the primary components, often bulked with caffeine and other adulterants to increase volume. (6) An analysis from the Erowid Center’s anonymous drug-testing program, DrugsData.org, shows that of the 68 samples submitted between 2016 and 2024 under labels “pink cocaine”, “tusi”, or “2C-B”, 94% contained ketamine (64 samples) and 81% contained MDMA (52 samples) (Figure 1). (8) Particularly concerning is the wide variety of additional adulterants also detected across these samples, including amphetamines, opioids, and tranquilizers. Given the widespread contamination of other illicit drugs with fentanyl, it may only be a matter of time before it or similarly potent opioids also find their way into batches of pink cocaine. Figure 1. Contents of the 68 sample submissions labeled as tusi/2C-B/pink cocaine to DrugsData between 2016 and 2024. (8) Ketamine precursor A = 1-[(2-chlorophenyl)(methylimino)methyl]cyclopentanol; MDMA = 3,4-methylenedioxymethamphetamine; MDA = 3,4-methylenedioxyamphetamine; bk-EBDB = β-keto-1,3-benzodioxolyl-<i>N</i>-ethylbutanamine (eutylone); DMT = <i>N</i>,<i>N</i>-dimethyltryptamine. Furthermore, in a closer look at 10 samples submitted between 2023 and 2024, ketamine was the dominant component, making up to approximately 40–90% of each sample, followed by MDMA in an approximately 10–45% concentration (Figure 2). Figure 2. Percentage of drugs detected within the 10 tusi/2C-B/pink cocaine submissions to DrugsData between 2023 and 2024. (8) When users are not aware of the strength, contents, or potential effects of what they are consuming, they are at significant risk for acute toxicity, misadventure, and overdose. For example, at low recreational doses (∼60 mg), ketamine might produce sensations of lightness, relaxation, and mild intoxication. (9) However, at higher doses, ketamine’s effects intensify, often leading to profound psychedelic experiences, pronounced dissociation, and significant loss of motor control. A high enough dose can produce a state known as a “K-hole”, where users may feel entirely detached from their body and surroundings. (10) Given this, a person who consumes a batch of pink cocaine that has a particularly high ketamine content can unintentionally find themself in an extremely disorienting and frightening dissociative state which can trigger dangerous levels of anxiety or panic. This state also poses a serious risk of physical harm, as users may lose the ability to protect themselves from falls and other dangerous situations. The complex and often unpredictable interactions between the cocktail of substances found in pink cocaine must be emphasized, as this can lead to amplified and synergistic effects beyond what each drug might cause on its own. Selected components found in pink cocaine and their properties and risks are highlighted in Table 1. This risk is further compounded by the prevalence of poly-drug use in recreational settings, where users often mix other substances including alcohol, potentially leading to larger than expected doses and dangerous combinations. (21) Particularly concerning is the mixing of ketamine with other central nervous system depressants such as opioids, which can cause unintended oversedation and potentially life-threatening respiratory depression, especially in people with pre-existing respiratory conditions. (22) Indeed, a significant number of reported ketamine-related deaths have involved this dangerous combination. (22) On the other hand, the simultaneous use of depressants and stimulants, such as ketamine with MDMA, can create a dangerous physiological state where the stimulant effects of one drug can mask the sedative effects of the other. This can make it difficult for users to gauge their level of intoxication and lead to the consumption of higher than intended doses, increasing the risk of overdose. Given pink cocaine’s rising prevalence in the public and the media, swift action is essential to protect people who are unaware of its dangers. Users may mistakenly believe they can predict the drug’s effects, despite having little knowledge of what substances and doses they’re consuming. While increased education and awareness are critical harm reduction strategies, other measures such as expanding access to reliable drug-testing kits and services could further empower individuals to make safer and more informed choices in this high-risk environment. Although the use of unregulated substances will always carry inherent dangers, these measures can mitigate the risks posed by pink cocaine (and other recreational drugs). Until pink cocaine loses its appeal and fades from popularity, prioritizing education and awareness remains key to safeguarding the public from its allure and hazards. We thank Paige Poppe for the design of the main graphic. This article references 22 other publications. 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引用次数: 0

Abstract

In recent months, a synthetic drug commonly referred to as “pink cocaine” has captured headlines, with notable public figures reportedly linked to its hidden dangers. (1,2) Public fascination with what appears to be a new and mysterious “designer” drug has spurred a slew of media attention. The reality is that pink cocaine is neither a new drug nor cocaine; rather, it’s an inconsistent and unpredictable formulation of existing drugs and adulterants─primarily ketamine and MDMA─branded with a distinctive rosy hue. This deceptive tactic, designed to lure and entice a new wave of recreational drug users, has little regard for the serious health risks posed by the complex and dangerous interactions among its components. Pink cocaine is an older phenomenon than the recent headlines suggest. It has been circulating in Colombia, where it is more commonly known as “tusi” or “tusibi”, since the late 2000s, with the earliest reports dating back to 2012. (3) The nicknames “tusibi” and the shortened “tusi” derive from a phonetic translation of “2C-B”, a hallucinogenic phenethylamine first synthesized by Alexander Shulgin in 1974. (4) Known to induce euphoria and hallucinations reportedly similar to a blend of MDMA and LSD, 2C-B belongs to the broader “2C-X family” of drugs (psychedelic phenethylamines containing 2,5-dimethoxy substitution) and was widely popular in the European rave and party scenes in the 1990s. In the late 2000s, 2C-B surfaced in Colombia’s vibrant nightlife, where its reputation as a “designer” drug began to solidify. The signature pink hue was introduced as a way to mask the unpleasant and harsh taste of 2C-B when consumed, the food coloring and aromatic additives transforming the drug into a visually enticing and instantly recognizable powder. The drug’s evolution to the pink cocaine product of today was driven by the surge in demand for 2C-B in the Colombian market. As supply chains struggled to keep up, dealers began cutting 2C-B with more accessible and cheaper psychoactive substances to mimic its stimulant and hallucinogenic effects. (5) Eventually, 2C-B disappeared from the formulation altogether, giving way to the current iterations of pink cocaine. Recently, law enforcement agencies and drug-checking services have reported an uptick in pink cocaine’s presence beyond Latin America, particularly in Europe and North America. (6,7) In the United States, pink cocaine has slowly gained popularity within the club scenes in New York, Miami, and Los Angeles. In 2023, multiple large-scale seizures in the U.S. further underscored its growing popularity. The primary danger of pink cocaine lies in the unknown. Not only is the name itself misleading, giving the illusion of a stimulant akin to cocaine, but the user is completely unaware of the cocktail of substances hidden beneath its appealing pink shade. Aside from the pink food coloring, little about this drug is consistent. Each batch varies widely in composition and potency, exposing users to a risky blend of substances with unpredictable polypharmacology and drug–drug interactions. While the exact amounts and ratios of its ingredients are uncertain, drug-checking studies across the globe have frequently revealed ketamine and MDMA as the primary components, often bulked with caffeine and other adulterants to increase volume. (6) An analysis from the Erowid Center’s anonymous drug-testing program, DrugsData.org, shows that of the 68 samples submitted between 2016 and 2024 under labels “pink cocaine”, “tusi”, or “2C-B”, 94% contained ketamine (64 samples) and 81% contained MDMA (52 samples) (Figure 1). (8) Particularly concerning is the wide variety of additional adulterants also detected across these samples, including amphetamines, opioids, and tranquilizers. Given the widespread contamination of other illicit drugs with fentanyl, it may only be a matter of time before it or similarly potent opioids also find their way into batches of pink cocaine. Figure 1. Contents of the 68 sample submissions labeled as tusi/2C-B/pink cocaine to DrugsData between 2016 and 2024. (8) Ketamine precursor A = 1-[(2-chlorophenyl)(methylimino)methyl]cyclopentanol; MDMA = 3,4-methylenedioxymethamphetamine; MDA = 3,4-methylenedioxyamphetamine; bk-EBDB = β-keto-1,3-benzodioxolyl-N-ethylbutanamine (eutylone); DMT = N,N-dimethyltryptamine. Furthermore, in a closer look at 10 samples submitted between 2023 and 2024, ketamine was the dominant component, making up to approximately 40–90% of each sample, followed by MDMA in an approximately 10–45% concentration (Figure 2). Figure 2. Percentage of drugs detected within the 10 tusi/2C-B/pink cocaine submissions to DrugsData between 2023 and 2024. (8) When users are not aware of the strength, contents, or potential effects of what they are consuming, they are at significant risk for acute toxicity, misadventure, and overdose. For example, at low recreational doses (∼60 mg), ketamine might produce sensations of lightness, relaxation, and mild intoxication. (9) However, at higher doses, ketamine’s effects intensify, often leading to profound psychedelic experiences, pronounced dissociation, and significant loss of motor control. A high enough dose can produce a state known as a “K-hole”, where users may feel entirely detached from their body and surroundings. (10) Given this, a person who consumes a batch of pink cocaine that has a particularly high ketamine content can unintentionally find themself in an extremely disorienting and frightening dissociative state which can trigger dangerous levels of anxiety or panic. This state also poses a serious risk of physical harm, as users may lose the ability to protect themselves from falls and other dangerous situations. The complex and often unpredictable interactions between the cocktail of substances found in pink cocaine must be emphasized, as this can lead to amplified and synergistic effects beyond what each drug might cause on its own. Selected components found in pink cocaine and their properties and risks are highlighted in Table 1. This risk is further compounded by the prevalence of poly-drug use in recreational settings, where users often mix other substances including alcohol, potentially leading to larger than expected doses and dangerous combinations. (21) Particularly concerning is the mixing of ketamine with other central nervous system depressants such as opioids, which can cause unintended oversedation and potentially life-threatening respiratory depression, especially in people with pre-existing respiratory conditions. (22) Indeed, a significant number of reported ketamine-related deaths have involved this dangerous combination. (22) On the other hand, the simultaneous use of depressants and stimulants, such as ketamine with MDMA, can create a dangerous physiological state where the stimulant effects of one drug can mask the sedative effects of the other. This can make it difficult for users to gauge their level of intoxication and lead to the consumption of higher than intended doses, increasing the risk of overdose. Given pink cocaine’s rising prevalence in the public and the media, swift action is essential to protect people who are unaware of its dangers. Users may mistakenly believe they can predict the drug’s effects, despite having little knowledge of what substances and doses they’re consuming. While increased education and awareness are critical harm reduction strategies, other measures such as expanding access to reliable drug-testing kits and services could further empower individuals to make safer and more informed choices in this high-risk environment. Although the use of unregulated substances will always carry inherent dangers, these measures can mitigate the risks posed by pink cocaine (and other recreational drugs). Until pink cocaine loses its appeal and fades from popularity, prioritizing education and awareness remains key to safeguarding the public from its allure and hazards. We thank Paige Poppe for the design of the main graphic. This article references 22 other publications. This article has not yet been cited by other publications.

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什么是粉色可卡因?多彩名字背后的黑暗现实
最近几个月,一种通常被称为“粉色可卡因”的合成药物登上了头条新闻,据报道,一些知名公众人物与这种药物的潜在危险有关。公众对一种看似神秘的新型“人造”毒品的痴迷,引发了媒体的广泛关注。事实是,粉色可卡因既不是一种新药,也不是可卡因;相反,它是现有药物和掺假剂──主要是氯胺酮和摇头丸──的一种不一致且不可预测的配方,并带有独特的玫瑰色。这种欺骗性的策略,旨在吸引和引诱新一波的娱乐性药物使用者,几乎没有考虑到其组成部分之间复杂和危险的相互作用所造成的严重健康风险。粉红色可卡因的现象比最近的头条新闻所显示的要久远。自2000年代末以来,它一直在哥伦比亚传播,在那里它更常被称为“tusi”或“tusibi”,最早的报道可以追溯到2012年。(3)绰号“tusibi”和简称“tusi”源于“2C-B”的音译,这是亚历山大·舒尔金于1974年首次合成的一种致幻苯乙胺。(4)据报道,2C-B具有类似于MDMA和LSD的混合物的兴奋感和幻觉,属于更广泛的“2C-X家族”的药物(含有2,5-二甲氧基取代的致幻剂苯乙胺),在20世纪90年代在欧洲的狂欢和派对场景中广泛流行。2000年代末,2C-B出现在哥伦比亚充满活力的夜生活中,它作为“设计师”毒品的名声开始巩固。采用标志性的粉色色调是为了掩盖2C-B在食用时令人不快和刺鼻的味道,食用色素和芳香添加剂将药物转化为视觉上诱人且易于识别的粉末。由于哥伦比亚市场对2C-B的需求激增,这种毒品演变成今天的粉红色可卡因产品。由于供应链难以跟上,经销商开始用更容易获得、更便宜的精神活性物质来减少2C-B,以模仿其刺激和致幻作用。最终,2C-B从配方中完全消失了,取而代之的是目前不断更新的粉色可卡因。最近,执法机构和毒品检查机构报告说,粉红色可卡因在拉丁美洲以外地区的存在有所增加,特别是在欧洲和北美。在美国,粉红可卡因在纽约、迈阿密和洛杉矶的俱乐部里慢慢流行起来。2023年,美国的多起大规模缉获进一步凸显了其日益受欢迎的程度。粉红色可卡因的主要危险在于未知。不仅这个名字本身具有误导性,给人一种类似可卡因的兴奋剂的错觉,而且使用者完全没有意识到在它诱人的粉红色阴影下隐藏着的各种物质的混合物。除了粉色食用色素外,这种药几乎没有一致性。每个批次的成分和效力差异很大,使使用者暴露在具有不可预测的多药理学和药物-药物相互作用的危险物质混合物中。虽然其成分的确切数量和比例尚不确定,但全球范围内的药物检查研究经常发现氯胺酮和MDMA是主要成分,通常会加入咖啡因和其他掺假物以增加体积。(6)来自Erowid中心匿名药物检测项目DrugsData.org的一项分析显示,在2016年至2024年间提交的68份标签为“粉色可卡因”、“tusi”或“2C-B”的样本中,94%含有氯胺酮(64份样本),81%含有MDMA(52份样本)(图1)。(8)特别令人担忧的是,在这些样本中还检测到各种各样的其他掺杂物,包括安非他明、阿片类药物和镇静剂。考虑到芬太尼在其他非法药物中的广泛污染,芬太尼或类似的强效阿片类药物也会进入成批的粉红色可卡因中,这可能只是时间问题。图1所示。2016年至2024年间提交给DrugsData的68份标签为tusi/2C-B/粉色可卡因的样本内容。(8)氯胺酮前体A = 1-[(2-氯苯基)(甲基)甲基]环戊醇;MDMA = 3,4-亚甲基二氧基甲基苯丙胺;MDA = 3,4-亚甲基二氧苯丙胺;bk-EBDB = β-酮-1,3-苯二氧基- n -乙基丁胺(真炔酮);DMT = N,N-二甲基色胺。此外,在2023年至2024年期间提交的10个样品中,氯胺酮是主要成分,占每个样品的约40-90%,其次是MDMA,浓度约为10 - 45%(图2)。2023年至2024年期间提交给DrugsData的10个tusi/2C-B/粉色可卡因中检测到的药物百分比。(8)当使用者不知道他们所食用的药物的强度、内容或潜在影响时,他们有发生急性毒性、意外事故和过量的重大风险。 例如,在低娱乐性剂量(~ 60毫克)下,氯胺酮可能会产生轻盈、放松和轻度中毒的感觉。(9)然而,高剂量氯胺酮的作用增强,常常导致深刻的迷幻体验,明显的解离,以及明显的运动控制丧失。足够高的剂量会产生一种被称为“k洞”的状态,在这种状态下,使用者可能会感觉与自己的身体和周围环境完全分离。有鉴于此,一个人如果吸食了一批氯胺酮含量特别高的粉红色可卡因,就会无意中发现自己处于一种极度迷失方向和可怕的分离状态,这种状态会引发危险程度的焦虑或恐慌。这种状态也会带来严重的身体伤害风险,因为使用者可能会失去保护自己免受跌倒和其他危险情况的能力。必须强调在粉色可卡因中发现的混合物质之间复杂且往往不可预测的相互作用,因为这可能导致放大和协同效应,超出每种药物本身可能造成的影响。表1突出显示了在粉色可卡因中发现的选定成分及其特性和风险。在娱乐场所普遍使用多种药物,使用者经常混合使用包括酒精在内的其他物质,这可能导致比预期剂量更大的剂量和危险的组合,从而进一步加剧了这一风险。(21)尤其令人担忧的是氯胺酮与阿片类药物等其他中枢神经系统抑制剂的混合,这可能导致意外的过度镇静和潜在的危及生命的呼吸抑制,特别是在已有呼吸系统疾病的人群中。(22)事实上,大量报告的与氯胺酮有关的死亡都涉及这种危险的组合。(22)另一方面,同时使用抑制剂和兴奋剂,如氯胺酮和MDMA,会造成一种危险的生理状态,其中一种药物的兴奋作用会掩盖另一种药物的镇静作用。这可能使使用者难以衡量自己的中毒程度,并导致服用高于预期剂量的药物,从而增加过量服用的风险。鉴于粉色可卡因在公众和媒体中日益流行,迅速采取行动保护那些不知道其危险的人至关重要。使用者可能会错误地认为他们可以预测药物的效果,尽管他们对服用的物质和剂量知之甚少。虽然加强教育和提高认识是关键的减少伤害战略,但其他措施,如扩大获得可靠的药物检测包和服务的机会,可进一步增强个人在这种高风险环境中作出更安全和更知情的选择的能力。尽管使用不受管制的物质总是会带来固有的危险,但这些措施可以减轻粉红可卡因(和其他娱乐性药物)带来的风险。在粉色可卡因失去吸引力、不再受欢迎之前,优先开展教育和提高认识仍然是保护公众免受其诱惑和危害的关键。我们感谢Paige Poppe设计的主要图形。本文引用了22个其他出版物。这篇文章尚未被其他出版物引用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry 医学-医药化学
CiteScore
4.00
自引率
11.00%
发文量
804
审稿时长
1.9 months
期刊介绍: The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.
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