Electrochemical sensor based on molecularly imprinted polypyrrole-MWCNTs-OH/covalent organic framework for the detection of ofloxacin in water

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-12-03 DOI:10.1007/s00604-024-06860-w

Lijuan Huang, Yuan Luo, Xulin Li, Juan Wu, Qian Long, Li Zheng, Wenlong Liao, Huiming Li, Lingpu Jia, Kunping Liu

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Abstract

A platform was developed to accurately detect the content of ofloxacin (OFX) based on molecularly imprinted polypyrrole-MWCNTs-OH/1,3,5-Tris(4-aminophenyl) benzene (TAPB)-2,5-dimethoxybenzene-1,4-dicarboxaldehyde (DMTP)-covalent organic framework (MIP-MWCNTs-OH/COF)–modified glassy carbon electrode (GCE) sensor (MIP-MWCNTs-OH/COF/GCE). The complex of MWCNTs-OH and COF synergistically enhanced the active area and electrochemical signal, based on which a molecularly imprinted membrane was polymerized on its surface to further improve the selectivity. Under optimized conditions, the prepared MIP-MWCNTs-OH/COF/GCE sensor exhibited strong detection performance to OFX in a linear range 1.969 × 10⁻¹¹–9.619 × 10⁻⁹ M with the limit of detection (LOD, 3S/N) of 4.989 × 10⁻¹² M, excellent selectivity, stability, and reproducibility. Furthermore, the MIP-MWCNTs-OH/COF/GCE sensor can be successfully applied to the detection of OFX in lake water and eye drops with a relative standard deviation (RSD) of less than 4.95%, indicating its high potential in practical applications.

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基于分子印迹聚吡咯- mwcnts - oh /共价有机骨架的电化学传感器检测水中氧氟沙星

基于分子印迹聚吡咯- mwcnts - oh /1,3,5-三（4-氨基苯基）苯(TAPB)-2,5-二甲氧基苯-1,4-二甲醛(DMTP)-共价有机框架(MIP-MWCNTs-OH/COF) -修饰玻璃碳电极（GCE）传感器（MIP-MWCNTs-OH/COF/GCE），建立了氧氟沙星（OFX）含量准确检测平台。MWCNTs-OH和COF配合物协同增强了活性区域和电化学信号，在此基础上在其表面聚合分子印迹膜，进一步提高了选择性。在优化条件下，制备的MIP-MWCNTs-OH/COF/GCE传感器在1.969 × 10−11-9.619 × 10−9 M线性范围内对OFX具有较强的检测性能，检出限（LOD, 3S/N）为4.989 × 10−12 M，具有良好的选择性、稳定性和重复性。此外，MIP-MWCNTs-OH/COF/GCE传感器可成功用于湖水和眼药水中OFX的检测，相对标准偏差（RSD）小于4.95%，具有较高的实际应用潜力。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.