Zhi Zhou, Zhensheng Lin, Ying Cai, Junwei Ye, Kaifeng Chen, Jieni Zheng, Linxin Zhou, Wei Yi
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引用次数: 0
Abstract
A variety of fluorinated 2H-chromenes and dihydroquinolines was synthesized by virtue of gem-difluoromethylene allenes as versatile coupling partners to participate in the transition metal-catalysed cascade C-H activation/[5+1] annulation of 2-alkenylphenols/anilines. This protocol features specific chemo-/regioselectivity, redox-neutral manner and good compatibility, providing a straightforward synthetic route to intriguing motifs with the equipment of attractive fluoroalkenyl moiety. The distinctive gem-difluorine effect induced an unexpected protonolysis of σ carbon-metal bond, thus accounting for the observed selectivity via sequential C-H activation/allene insertion/protonolysis/cyclization/β-F elimination process.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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