{"title":"Schiff Base-platinum and ruthenium complexes and anti-Alzheimer properties.","authors":"Salih Günnaz, Esma Yildiz, Ayça Tunçel Oral, Fatma Yurt, Arzum Erdem, Sevil Irişli","doi":"10.1016/j.jinorgbio.2024.112790","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (<sup>1</sup>H, <sup>13</sup>C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ<sub>1-42</sub>) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of Aβ<sub>1</sub><sub>-</sub><sub>42</sub> with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and <sup>1</sup>H NMR spectroscopy examined the interaction with Aβ<sub>1</sub><sub>-</sub><sub>16</sub>. Electrochemical analysis using square wave voltammetry monitored the interaction with Aβ<sub>1</sub><sub>-</sub><sub>42</sub>. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.</p>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"264 ","pages":"112790"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jinorgbio.2024.112790","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (1H, 13C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ1-42) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of Aβ1-42 with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 1H NMR spectroscopy examined the interaction with Aβ1-16. Electrochemical analysis using square wave voltammetry monitored the interaction with Aβ1-42. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.
期刊介绍：
The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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