Sulfation pathways in times of change.

IF 5.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Essays in biochemistry Pub Date : 2024-12-04 DOI:10.1042/EBC20230099
Jonathan Wolf Mueller, Daniela Fietz, Irundika H K Dias
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Abstract

Sulfation pathways are an essential part of overall sulfur metabolism. Sulfation pathways are mainly about sulfate activation, and the making and breaking of biological sulfate esters. This special issue features some extended reflection on what was presented at the SUPA 2023 meeting on Sulfation Pathways. Novel insights into the synthesis and analytics of sulfate, of sulfated conjugates, and of protein persulfides are presented. Oxysterol sulfates are presented as emerging sulfo-metabolites. Sulfation pathways enzymes are discussed in various disease settings. This special issue also presents insights into polysaccharide sulfotransferases and their functional characterization. Finally, cytoplasmic sulfotransferases are highlighted with regards to their impact on DNA-modification, and in the context of endocrine disruptors. All in all, thought-provoking findings, with the potential to guide and stimulate future research in the field of sulfation pathways and beyond.

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变化时代的磺化途径。
硫酸化途径是整个硫代谢的重要组成部分。硫酸酸化途径主要是硫酸盐活化、生物硫酸酯的生成和破坏。本期特刊对SUPA 2023年磺化途径会议上提出的内容进行了一些扩展思考。新见解的合成和分析硫酸盐,硫酸偶联物,并提出了蛋白质过硫化物。硫酸氧甾醇是一种新兴的亚硫酸盐代谢物。硫酸化途径酶在各种疾病的设置进行了讨论。本期特刊还介绍了多糖硫转移酶及其功能表征。最后,细胞质硫转移酶强调了它们对dna修饰和内分泌干扰物的影响。总而言之,这些发人深省的发现,有可能指导和刺激未来在硫酸化途径及其他领域的研究。
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来源期刊
Essays in biochemistry
Essays in biochemistry 生物-生化与分子生物学
CiteScore
10.50
自引率
0.00%
发文量
105
审稿时长
>12 weeks
期刊介绍: Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.
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