Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Hearing Research Pub Date : 2025-01-01 DOI:10.1016/j.heares.2024.109154

Elizabeth S. Olson , Wei Dong , Brian E. Applegate , Karolina K. Charaziak , James B. Dewey , Brian L. Frost , Sebastiaan W.F. Meenderink , Jong-Hoon Nam , John S. Oghalai , Sunil Puria , Tianying Ren , C. Elliott Strimbu , Marcel van der Heijden

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Abstract

Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears.

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视觉运动在Corti的耳蜗器官和照明耳蜗力学光学相干断层扫描。

从2006年开始，光学相干断层扫描（OCT）已被用作听力研究中的测振仪。OCT在这一领域的应用，特别是在研究耳蜗力学方面的应用，代表了以往技术的革命性进步。OCT提供了Corti器官内部件运动的详细证据，超出了第一次遇到的观察表面。通过骨囊和圆窗膜成像，OCT在体内几乎自然的条件下沿着耳蜗螺旋测量了多个位置的振动。在本文中，我们列举了最近的研究成果，以说明OCT在研究正常和受损耳蜗力学方面的应用。

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来源期刊

Hearing Research 医学-耳鼻喉科学

CiteScore

5.30

自引率

14.30%

发文量

163

审稿时长

75 days

期刊介绍： The aim of the journal is to provide a forum for papers concerned with basic peripheral and central auditory mechanisms. Emphasis is on experimental and clinical studies, but theoretical and methodological papers will also be considered. The journal publishes original research papers, review and mini- review articles, rapid communications, method/protocol and perspective articles. Papers submitted should deal with auditory anatomy, physiology, psychophysics, imaging, modeling and behavioural studies in animals and humans, as well as hearing aids and cochlear implants. Papers dealing with the vestibular system are also considered for publication. Papers on comparative aspects of hearing and on effects of drugs and environmental contaminants on hearing function will also be considered. Clinical papers will be accepted when they contribute to the understanding of normal and pathological hearing functions.