Hearing Research最新文献

Exploring the relationship between task difficulty, head-related transfer function and spatial release from masking in a speech-on-speech experiment. 在语音对语音实验中探讨任务难度、头部相关传递函数和空间释放与掩蔽的关系。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-06 DOI: 10.1016/j.heares.2025.109490

Thibault Vicente, Daniel González-Toledo, María Cuevas-Rodríguez, Luis Molina-Tanco, Arcadio Reyes-Lecuona, Lorenzo Picinali

It is known that individuals make use of spatial hearing cues to improve the audibility of a target signal and separate it from competing sounds. This phenomenon is known as spatial release from masking (SRM). Recent research has shown that this happens also when sources are located in the median plane, where interaural differences are limited. When assessing this within virtual conditions, it has been shown that employing individually measured head-related transfer functions (HRTFs) results in higher SRM abilities compared to using non-individual filters. In a previously published work, we found that Spanish speakers benefit from individual HRTFs when discriminating a target English speech from a single masker in the median plane. This study replicates the protocol of that previous work, varying the number of maskers and participants' English proficiency levels to explore relationships among task difficulty and HRTF use. Results from a first experiment show that English speakers behave differently to Spanish ones; their SRM advantage is not significant. We suggest that this is due to their language proficiency, which allows them to rely on spectral glimpsing alone, that is, exploiting spectro-temporal gaps between voices rather than spectral cues introduced by spatial separation. A second experiment introduces a second speech masker, co-located with the first; by making the task more complex, participants seem to increase their reliance on spatial cues, resulting in significant effects of masker position and HRTF. This highlights a trade-off between the use of target glimpsing and spatial cues and the need for further exploration into how task difficulty influences SRM with different HRTFs.

众所周知，个体利用空间听觉线索来提高目标信号的可听性，并将其与竞争声音区分开来。这种现象被称为空间掩蔽释放（SRM）。最近的研究表明，当声源位于中间平面时也会发生这种情况，因为中间平面的内部差异有限。当在虚拟条件下评估这一点时，已经表明，与使用非单个过滤器相比，使用单独测量的头部相关传递函数（hrtf）可以获得更高的SRM能力。在之前发表的一篇文章中，我们发现说西班牙语的人在区分目标英语语音和中间平面的单个掩码时，可以从单个hrtf中受益。本研究复制了先前研究的方案，改变了蒙面者的数量和参与者的英语熟练程度，以探索任务难度和HRTF使用之间的关系。第一个实验的结果表明，说英语的人和说西班牙语的人表现不同；他们的SRM优势并不显著。我们认为这是由于他们的语言熟练程度，这使得他们能够仅仅依靠光谱瞥见，也就是说，利用声音之间的光谱-时间间隙，而不是空间分离带来的光谱线索。第二个实验引入了第二个语音掩码器，与第一个掩码器位于同一位置；通过使任务更复杂，参与者似乎增加了对空间线索的依赖，从而导致蒙面位置和HRTF的显著影响。这突出了目标瞥见和空间线索的使用之间的权衡，以及进一步探索任务难度如何影响不同hrtf的SRM的必要性。

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引用次数: 0

Sex-specific hearing loss in Sirt3 knockout mice and attenuation by honokiol Sirt3基因敲除小鼠的性别特异性听力损失和本木酚的衰减

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-02 DOI: 10.1016/j.heares.2025.109502

Chail Koo , Yingjie Zhou , Devin Thomas , Robert Fuentes , Jin Li , Matthew Kim , Claus-Peter Richter , Xiaodong Tan

Sirtuin 3 (SIRT3) is a mitochondrial deacetylase that regulates redox balance and cellular stress resistance. Its role in hearing maintenance under basal conditions is controversial. Here, we investigated the effect of Sirt3 deficiency on auditory function and studied whether honokiol, a small-molecule SIRT3 activator, provides protection in the cochlea.

Male and female Sirt3^+/+, Sirt3^+/−, and Sirt3^−/− mice were assessed for auditory brainstem response thresholds at 6, 8, and 12 weeks of age. Mice were given honokiol via intraperitoneal injection at weeks 6, 8, and 10. Synapse integrity, hair cell survival, antioxidant enzyme activity, hydrogen peroxide levels, and gene expression were studied in the cochlea. Generalized linear mixed-effects models were used to investigate the interaction between genotype, frequency, age, and treatment on auditory brainstem response thresholds.

Male Sirt3^−/− mice showed early-onset, progressive hearing loss, with reduced postsynaptic densities. Honokiol treatment preserved hearing thresholds, increased SIRT3 signal in wild-type mice, and increased SIRT5 signal in male Sirt3^−/− mice. In male Sirt3^−/− mice, honokiol did not restore presynaptic or postsynaptic puncta numerically, but restored presynaptic morphology. Honokiol treatment improved superoxide dismutase 2 enzymatic activity, decreased cochlear hydrogen peroxide levels, and upregulated Sirt5 mRNA expression in male Sirt3^−/− cochleae. Linear mixed-effects modeling identified genotype, frequency, and interactions of fixed effects with honokiol treatment as significant predictors of auditory brainstem response thresholds.

This study demonstrates that SIRT3 is required for hearing function and that honokiol attenuates hearing loss and oxidative stress in male Sirt3^−/− mice.

Sirtuin 3 （SIRT3）是一种线粒体去乙酰化酶，调节氧化还原平衡和细胞抗逆性。它在基础条件下听力维持中的作用是有争议的。在此，我们研究了Sirt3缺乏对听觉功能的影响，并研究了小分子Sirt3激活剂honokiol是否在耳蜗中提供保护。雄性和雌性Sirt3+/+、Sirt3+/−和Sirt3−/−小鼠在6、8和12周龄时评估听觉脑干反应阈值。小鼠分别于第6、8、10周腹腔注射厚朴酚。研究了耳蜗突触完整性、毛细胞存活、抗氧化酶活性、过氧化氢水平和基因表达。使用广义线性混合效应模型来研究基因型、频率、年龄和治疗对听觉脑干反应阈值的相互作用。雄性Sirt3−/−小鼠表现为早发性进行性听力丧失，突触后密度降低。本木酚处理保留了听觉阈值，增加了野生型小鼠的SIRT3信号，增加了雄性SIRT3 - / -小鼠的SIRT5信号。在雄性Sirt3 - / -小鼠中，厚木酚并没有在数值上恢复突触前或突触后的点，但恢复了突触前的形态。本木酚处理提高了超氧化物歧化酶2酶活性，降低了耳蜗过氧化氢水平，上调了雄性耳蜗Sirt3−/−的Sirt5 mRNA表达。线性混合效应模型确定了基因型、频率和固定效应与厚木酚治疗的相互作用是听觉脑干反应阈值的重要预测因子。这项研究表明，SIRT3是听力功能所必需的，而厚木酚可以减轻雄性SIRT3−/−小鼠的听力损失和氧化应激。

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引用次数: 0

Evidence for evolutionary divergence in temporal integration windows between human and monkey auditory cortex 人类和猴子听觉皮层时间整合窗口进化差异的证据。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-27 DOI: 10.1016/j.heares.2025.109489

Pradeep Dheerendra , Christopher I. Petkov , Adrian Rees , Timothy D. Griffiths

The cortical representation of the temporal dimension of sound in the primate auditory cortex remains an open question. In this work, we review studies that investigated the brain basis for the processing of acoustic time windows in humans, macaques and marmosets that employ functional magnetic resonance imaging and neurophysiological recordings. We identify the functional anatomy of response patterns to temporal integration for each study, to arrive at a representative organization in humans and non-human primates (NHP). A synthesis of prior studies identifies a certain level of commonality for temporal processing in primates. Surprisingly, however, our analysis revealed that while both humans and NHPs process shorter time-windows in postero-medial areas and longer time-windows in non-primary lateral areas, macaque neurobiological responses in primary auditory cortex appear to favor shorter temporal timescales than human primary auditory cortex. This difference in neurobiological sensitivity is in line with behavioural sensitivities in these species. This review and analysis results raise the possibility of evolutionary specialization of the human cortex relative to nonhuman primates, potentially for the processing of speech which requires sensitivity to longer timescales.

灵长类动物听觉皮层中声音的时间维度的皮层表征仍然是一个悬而未决的问题。在这项工作中，我们回顾了利用功能磁共振成像和神经生理记录研究人类、猕猴和狨猴声学时间窗处理的大脑基础的研究。我们为每项研究确定了对时间整合的反应模式的功能解剖，以达到人类和非人类灵长类动物（NHP）的代表性组织。综合先前的研究发现，灵长类动物的时间处理有一定程度的共性。然而，令人惊讶的是，我们的分析显示，尽管人类和NHPs在后内侧区域处理的时间窗更短，而非初级外侧区域处理的时间窗更长，但猕猴初级听觉皮层的神经生物学反应似乎比人类初级听觉皮层更倾向于更短的时间尺度。这种神经生物学敏感性的差异与这些物种的行为敏感性一致。这一综述和分析结果提出了人类皮层相对于非人类灵长类动物的进化专一化的可能性，潜在地用于需要对更长的时间尺度敏感的语言处理。

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引用次数: 0

Automated high-fidelity 3D reconstruction of middle-ear ossicles from low-resolution clinical CT using a deep learning pipeline 利用深度学习管道对低分辨率临床CT进行中耳小骨自动高保真三维重建。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-26 DOI: 10.1016/j.heares.2025.109492

Jongyeon Yoon , Jeongsan Kim , Jongwoo Lim , Ivo Dobrev , Christof Röösli , Seungchul Lee , Il Joon Moon , Namkeun Kim

This study validates an automated deep learning framework for generating high-fidelity 3D models of the middle-ear ossicles from low-resolution clinical CT images. The framework employs a sequential three-stage pipeline: (1) accurate Region of Interest (ROI) detection using YOLOv5x, (2) 4x super-resolution of the ROI with a Deep Back-Projection Network (DBPN), and (3) slice interpolation using a 2.5D U-Net to create a dense volumetric dataset. To ensure robust reconstruction from incomplete data, the interpolation stage integrates a "hint channel" that leverages anatomical priors. The framework demonstrated high accuracy, achieving a mean Average Precision (mAP50) of 0.9835 for ROI detection and producing final 3D models with a high degree of anatomical fidelity (Dice coefficient: 0.85; and mean surface distance: 4.8 µm). The hint channel's efficacy was most evident on an external inference set, where it successfully generated complete ossicular structures that were otherwise omitted due to sparse source information, demonstrating the model's strong generalization. Furthermore, the entire automated process, from CT scan to final 3D model, was completed within 5 min, offering a substantial improvement in workflow efficiency compared to manual methods that require approximately more than 20 min. The proposed framework is thus validated as a rapid, accurate, and robust tool for generating patient-specific 3D ossicle models from standard clinical CTs. This technology is expected to enhance the accuracy of biomechanical finite element simulations and serves as a foundational step toward advancing precision medicine in otologic surgery and custom prosthesis design.

本研究验证了一种自动深度学习框架，用于从低分辨率临床CT图像中生成中耳小骨的高保真3D模型。该框架采用了一个连续的三阶段管道：(1)使用YOLOv5x进行精确的感兴趣区域（ROI）检测，(2)使用深度反向投影网络（DBPN）对感兴趣区域进行4倍的超分辨率检测，以及(3)使用2.5D U-Net进行切片插值，以创建密集的体积数据集。为了确保不完整数据的鲁棒重建，插值阶段集成了一个利用解剖先验的“提示通道”。该框架具有很高的精度，ROI检测的平均平均精度（mAP50）为0.9835，最终生成的3D模型具有很高的解剖保真度（Dice系数：0.85，平均表面距离：4.8µm）。提示通道的有效性在外部推理集上最为明显，它成功地生成了完整的听骨结构，否则由于源信息稀疏而被忽略，这证明了模型的强泛化性。此外，从CT扫描到最终3D模型的整个自动化过程在5分钟内完成，与需要大约20多分钟的手动方法相比，大大提高了工作流程效率。因此，该框架被证实是一种快速、准确和强大的工具，可从标准临床ct生成患者特异性的3D听骨模型。这项技术有望提高生物力学有限元模拟的准确性，并作为推进耳科外科和定制假体设计的精准医学的基础步骤。

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引用次数: 0

Validating a rapid psychophysical procedure for estimating interaural time difference thresholds 验证一个快速的心理物理程序估计间时差阈值。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-26 DOI: 10.1016/j.heares.2025.109491

Justin M. Aronoff , Jordan Deutsch , Josephine R. LaPapa , Karla Rodriguez , Leslie R. Bernstein

The detection and discrimination of interaural time differences (ITDs) underpin many binaural abilities. Obtaining precise “threshold”-ITDs is, however, often quite time consuming. This study investigated the use of a rapid, descending series procedure to estimate threshold-ITDs. The procedure involves beginning with a suprathreshold ITD and then decreasing the ITD over sequential trials independent of response accuracy, ending with subthreshold ITDs. Normal hearing participants were tested using both an adaptive and descending series procedure. The results from the two procedures were comparable, while the descending series procedure required approximately half the time to complete as did the adaptive procedure. A function was determined for estimating ITD thresholds from the number of correct responses obtained with the descending series procedure. The results indicate that a descending series procedure is an efficient approach for estimating threshold-ITDs.

耳间时间差的检测和辨别是许多双耳能力的基础。然而，获得精确的“阈值”-过渡段通常非常耗时。本研究探讨了一种快速下降级数法来估计阈值过渡段。这个过程包括从一个超过阈值的过渡段开始，然后在与响应精度无关的连续试验中减少过渡段，以低于阈值的过渡段结束。听力正常的参与者使用自适应和下降系列程序进行测试。两种方法的结果具有可比性，而降序法和自适应法只需大约一半的时间即可完成。根据降序法得到的正确响应数，确定了一个估计过渡段阈值的函数。结果表明，降序法是估计阈值过渡段的有效方法。

引用次数: 0

Impact of age and sensorineural hearing loss on sound transmission to the inner ear based on analysis of air-bone gaps 基于气骨间隙分析的年龄和感音神经性听力损失对内耳声音传递的影响

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-24 DOI: 10.1016/j.heares.2025.109488

Stefan Stenfelt, Filip Wiman

Air-bone gaps (ABGs) provide a clinical marker of middle ear transmission efficiency, yet their dependence on age and sensorineural hearing loss remains unclear. We retrospectively analyzed 24,570 audiograms (13,417 patients, 4–102 years) collected at three Swedish audiology clinics between 2018 and 2019, excluding ears with evidence of conductive pathology. ABGs were computed from pure-tone air conduction (AC) and bone conduction (BC) thresholds at 250–4000 Hz. Mean ABGs deviated significantly from 0 dB at all six test frequencies, with clinically relevant differences at 250, 1000, 3000, and 4000 Hz. Children and adolescents showed systematically larger ABGs than adults, consistent with age-dependent craniofacial and BC transmission differences. In adults, ABGs decreased with age at 500 Hz and 2 kHz and increased at 250 Hz, 3 kHz, and 4 kHz, with differences depending on whether analyses included all adults or only adults with normal hearing. These age-dependent patterns likely reflect changes in soft tissue at the BC transducer and middle ear stiffness. Threshold-related effects were strongest at 250 and 500 Hz when ABGs were referenced to AC thresholds, where BC transducer distortion and vibrotactile responses likely contributed. Across frequencies, ABG distributions were predominantly positively skewed, with values ranging between -0.21 and 0.55. These findings demonstrate that even if ABGs vary with age and hearing threshold, the influence from middle ear transmission is minor. Instead, most of the systematic variations of ABGs relate to methodological constraints, underscoring the importance of careful interpretation of ABGs in clinical diagnostics.

气骨间隙（ABGs）是中耳传输效率的临床标志，但其与年龄和感音神经性听力损失的关系尚不清楚。我们回顾性分析了2018年至2019年期间在瑞典三家听力学诊所收集的24,570张听图（13,417例患者，4-102岁），排除了有传导性病理证据的耳朵。ABGs由250-4000 Hz的纯音空气传导（AC）和骨传导（BC）阈值计算。在所有6个测试频率下，平均ABGs都明显偏离0 dB，在250、1000、3000和4000 Hz时存在临床相关差异。儿童和青少年表现出系统性的比成人更大的abg，这与年龄依赖性颅面和BC传播差异一致。在成人中，ABGs在500 Hz和2 kHz时随年龄下降，在250 Hz、3 kHz和4 kHz时增加，差异取决于分析是否包括所有成年人或仅包括听力正常的成年人。这些与年龄相关的模式可能反映了BC换能器和中耳硬度软组织的变化。当ABGs参考交流阈值时，阈值相关效应在250和500 Hz时最强，其中BC换能器失真和振动触觉响应可能起作用。跨频率，ABG分布主要为正偏斜，其值在-0.21至0.55之间。这些发现表明，即使ABGs随年龄和听力阈值而变化，中耳传播的影响也很小。相反，大多数abg的系统性变异与方法学上的限制有关，这强调了在临床诊断中仔细解释abg的重要性。

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引用次数: 0

Smoking history and the rate of hearing decline in aging: Results from a longitudinal cohort study 吸烟史与老年听力下降率：一项纵向队列研究的结果

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-24 DOI: 10.1016/j.heares.2025.109486

Lauren K Dillard , Lois J Matthews , Kathleen E Bainbridge , Jada M Johnson , Judy R Dubno

Hearing loss is a common and impactful condition among aging adults. Improved understanding of modifiable risk factors for hearing loss, including smoking, could promote hearing loss prevention. The purpose of this longitudinal study was to determine the association of smoking with the rate of age-related hearing decline across the frequency range. Participants were from the Medical University of South Carolina Longitudinal Cohort Study of Age-related Hearing Loss. Smoking pack years were calculated (at baseline) as the number of self-reported packs smoked per day multiplied by years smoked, and categorized as 0, >0 to 5, >5 to 15, and >15 pack years. Outcome measures were individual audiometric thresholds (0.25 to 8.0 kHz) and pure-tone average (PTA) of thresholds at frequencies 0.5 to –4.0 kHz, averaged bilaterally. We used linear mixed regression models to determine the association of pack years with the rate of annual threshold change at each frequency and PTA. This study included 1032 participants (mean age: 63.3 [SD 14.1] years, mean follow-up time: 5.4 [SD 6.0] years; 60.4 % female; 21.7 % Black race). Compared to non-smokers (0 pack years), participants with >15 pack years had poorer baseline thresholds at frequencies 2.0 to 8.0 kHz and PTA. Compared to non-smokers, participants with >5 to 15 and >15 pack years had higher rates of annual threshold change at frequencies ranging from 1.0 to 8.0 kHz and PTA. Findings corroborate smoking as a possible modifiable risk factor for hearing loss that could have lasting impacts on hearing.

听力损失是老年人中常见的影响因素。提高对包括吸烟在内的可改变的听力损失风险因素的了解，可以促进听力损失的预防。这项纵向研究的目的是确定吸烟与整个频率范围内与年龄相关的听力下降率的关系。参与者来自南卡罗来纳医科大学年龄相关性听力损失纵向队列研究。吸烟包年的计算（基线）为每天自我报告的吸烟包数乘以吸烟年数，并分为0、0 - 5、5 - 15和15包年。结果测量是个体听力阈值（0.25至8.0 kHz）和频率为0.5至-4.0 kHz的阈值的纯音平均值（PTA），平均为双侧。我们使用线性混合回归模型来确定包年与各频率和PTA的年阈值变化率的关系。本研究纳入1032名参与者（平均年龄：63.3 [SD 14.1]岁，平均随访时间：5.4 [SD 6.0]年；60.4%为女性；21.7%为黑人）。与不吸烟者（0包年）相比，吸烟15包年的参与者在频率2.0至8.0 kHz和PTA上的基线阈值较低。与不吸烟者相比，吸烟5 - 15和15包年的参与者在1.0 - 8.0 kHz和PTA频率范围内的年阈值变化率更高。研究结果证实，吸烟可能是听力损失的一个可改变的风险因素，可能对听力产生持久影响。

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引用次数: 0

Bridging the gap: mechanisms and novel translational strategies to prevent cisplatin-induced ototoxicity 弥合差距：机制和新的转化策略，以防止顺铂诱导的耳毒性

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-24 DOI: 10.1016/j.heares.2025.109487

Jie Bai, Wenjia Wang, Zeming Fu, Jingpu Yang, Yingyuan Guo, Guofang Guan

Cisplatin is a widely used chemotherapeutic agent, but its clinical utility is limited by dose-dependent ototoxicity, causing irreversible sensorineural hearing loss and significantly impairing quality of life, especially in pediatric patients. This review aims to systematically examines the molecular mechanisms underlying cisplatin-induced ototoxicity and evaluate both current and emerging preventive strategies. We find that the central pathological process involves a self-perpetuating cycle of oxidative stress and immune-inflammatory responses within the cochlea, ultimately triggering the programmed death of hair cells. We critically appraise current pharmacological interventions, noting that while antioxidants, anti-inflammatory agents, and targeted delivery strategies demonstrate partial protection, their efficacy is constrained by single-target approaches, trade-offs between efficacy and safety, and interpatient variability. In contrast, emerging strategies—including nanotechnology-based drug delivery, gene therapy, epigenetic modulation, stem cell transplantation, and artificial intelligence-driven personalized interventions—offer multi-mechanistic, targeted, and potentially more effective alternatives. These emerging strategies, grounded in a detailed understanding of the core mechanisms, highlight the need for integrative, precision-focused otoprotective strategies and provide a theoretical foundation to guide future translational research.

顺铂是一种广泛使用的化疗药物，但其临床应用受到剂量依赖性耳毒性的限制，可引起不可逆的感音神经性听力损失，并显着降低生活质量，特别是在儿科患者中。本综述旨在系统地研究顺铂诱导耳毒性的分子机制，并评估当前和新兴的预防策略。我们发现核心病理过程涉及耳蜗内氧化应激和免疫炎症反应的自我延续循环，最终引发毛细胞的程序性死亡。我们批判性地评估了目前的药物干预措施，注意到虽然抗氧化剂、抗炎剂和靶向递送策略显示出部分保护作用，但它们的功效受到单靶点方法、疗效和安全性之间的权衡以及患者间可变性的限制。相比之下，新兴的策略——包括基于纳米技术的药物输送、基因治疗、表观遗传调节、干细胞移植和人工智能驱动的个性化干预——提供了多机制的、有针对性的、潜在更有效的替代方案。这些新兴策略基于对核心机制的详细理解，强调了对综合、精确的耳保护策略的需求，并为指导未来的转化研究提供了理论基础。

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引用次数: 0

3D Otoscope: toward an extra diagnostic dimension for middle-ear related issues 3D耳镜：为中耳相关问题提供额外的诊断维度

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-23 DOI: 10.1016/j.heares.2025.109485

William Keustermans , Peter ter Heerdt , Joris JJ Dirckx , Sam Van der Jeught

We present an industrially manufacturable digital otoscope designed to measure the three-dimensional shape of the tympanic membrane while being compatible with standard examination procedures. The system employs optical profilometry and overcomes the limitations of previous work by integrating single-shot surface reconstruction strategies—from classical Fourier profilometry to modern deep learning methods—thereby eliminating the need for multi-pattern projection and, in the latter case, even phase unwrapping. A full-field three-dimensional surface map enables the assessment of the tympanic membrane’s conical shape and mobility – both early indicators of pathologies such as local spots of high or low compliance, inflammation, or Eustachian tube dysfunction. This approach enables a drastically simplified hardware setup. As a result, the technology could in the future even be integrated into existing diagnostic instruments. This paper describes the optical and design considerations that guided the development of the prototype. Integration of the optical engine and simplified projection unit into a demonstrator device marks a crucial step toward dynamic deformation and volumetric displacement measurements of the tympanic membrane in clinical practice.

我们提出了一种工业制造的数字耳镜，用于测量鼓膜的三维形状，同时与标准检查程序兼容。该系统采用光学轮廓术，并通过集成单镜头表面重建策略（从经典的傅立叶轮廓术到现代深度学习方法）克服了先前工作的局限性，从而消除了对多模式投影的需求，在后者的情况下，甚至不需要相位展开。全景三维表面图可以评估鼓膜的锥形形状和活动性，这两者都是病理的早期指标，如局部斑点的高或低顺应性、炎症或咽鼓管功能障碍。这种方法大大简化了硬件设置。因此，这项技术在未来甚至可以集成到现有的诊断仪器中。本文描述了指导原型开发的光学和设计考虑。将光学引擎和简化投影单元集成到演示装置中，标志着在临床实践中向鼓膜动态变形和体积位移测量迈出了关键的一步。

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引用次数: 0

Frequency-dependent assessment of eardrum lesions using multisine OCT vibrometry 使用多正弦OCT振动仪对耳膜病变的频率依赖性评估

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-22 DOI: 10.1016/j.heares.2025.109481

P. Livens , S. Van der Jeught , J.J.J. Dirckx , A. Bradu

Optical coherence tomography (OCT) vibrometry is a promising tool for middle-ear mechanics, but single-frequency approaches limit efficiency and diagnostic power. We introduce multisine OCT vibrometry in a rabbit model to capture broadband, frequency-dependent eardrum vibrations acquired in a single OCT volume. Multisine data revealed that control ears had maximal umbo displacement at 1.4 kHz with an amplitude of 86

\pm

11 nm (N=5). Proof-of-concept measurements were performed to highlight the diagnostic value of detecting pathology related shifts in umbo displacement using multisines. Local thinning of the eardrum by ablation decreased the frequency of maximal displacement to 1.0 kHz and resulted in an umbo displacement of 84

\pm

4 nm. In contrast, perforation of the eardrum caused an overall drop in displacement amplitude across frequencies, with a maximal displacement of 34

\pm

3 nm reached at 2 kHz.

Additionally, the single multisine OCT volume allowed visualization of the eardrum’s displacement across the surface for all multisine tones. Ablation and perforations caused localized changes of the eardrum’s displacement at frequencies above 4 kHz.

Thus, multisine OCT vibrometry holds promise for improved diagnosis and surgical planning: umbo frequency-displacement curves can distinguish between healthy and pathological ears, while spatial displacement maps reveal lesion-specific displacement patterns at high frequencies.

光学相干层析成像（OCT）振动测量是一种很有前途的中耳力学工具，但单频方法限制了效率和诊断能力。我们在兔子模型中引入了多正弦OCT振动仪，以捕获单个OCT体积中获得的宽带、频率相关的耳膜振动。多重正弦数据显示，对照耳在1.4 kHz时的最大肿块位移为86±11 nm （N=5）。进行概念验证测量，以强调使用多重线检测脐移位病理相关移位的诊断价值。经消融术使鼓膜局部变薄，最大位移频率降至1.0 kHz，造成84±4 nm的肿块位移。相比之下，鼓膜穿孔导致不同频率的位移幅度整体下降，在2 kHz时最大位移达到34±3 nm。此外，单个多正弦OCT体积可以显示鼓膜在所有多正弦音调表面上的位移。在频率高于4khz时，消融术和穿孔引起耳膜位移的局部改变。因此，多正弦OCT振动仪有望改善诊断和手术计划：低频位移曲线可以区分健康和病理耳朵，而空间位移图显示高频病变特异性位移模式。

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引用次数: 0