Knowledge and perspectives towards the use of histology in inflammatory bowel disease by gastroenterologists across the Asia-Pacific region.

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY Intestinal Research Pub Date : 2024-12-02 DOI:10.5217/ir.2024.00086

Thanaboon Chaemsupaphan, Aviv Pudipeddi, Huiyu Lin, Hsin-Yun Wu, Julajak Limsrivilai, Wee Chian Lim, Shu-Chen Wei, Rupert W Leong

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Abstract

Background/aims: Recently, histological mucosal assessment has gained momentum as a potential new treatment target for patients with inflammatory bowel disease (IBD) in the Asia-Pacific region. This study aimed to evaluate and compare the knowledge and acceptability of histological assessment among gastroenterologists across the region.

Methods: A cross-sectional survey among gastroenterologists in the Asia-Pacific region was conducted and compared against a previous Australian survey. The questionnaire assessed knowledge and attitude towards the role and application of histology in IBD practice. Statistical analyses were employed to compare scores and identify predictors.

Results: A total of 221 gastroenterologists from 12 countries, including 77 (34.8%) from Australia, responded to questionnaire, with 185 (83.7%) completing the survey. The mean knowledge score was 9.8 ± 3.3 (51.6%). There was no significant difference in the average score among countries (P= 0.53). IBD specialist (P< 0.01), doctoral degree (P= 0.02), and regular participation in IBD multidisciplinary meetings (P= 0.01) were associated with higher scores. Most respondents (90.7%) agreed on the importance of histology in IBD. While 54.6% of Australians perceived the role of histology as established, only 37.0% of Asians respondents considered this similarly (P= 0.02). Histological activity alone minimally influences treatment escalation in patients with endoscopic remission, but achieving combined histo-endoscopic remission often leads to therapy de-escalation.

Conclusions: Although gastroenterologists in the Asia-Pacific region are aware of the role of histology in IBD, their knowledge remains limited, and its clinical utility is not widely adopted. There is a need to promote the routine use of standardized histological assessment in IBD practice.

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亚太地区胃肠病学家在炎性肠病中使用组织学的知识和观点。

背景/目的：最近，组织学粘膜评估作为炎症性肠病（IBD）患者的潜在新治疗靶点在亚太地区获得了发展势头。本研究旨在评估和比较该地区胃肠病学家对组织学评估的认识和可接受性。方法：对亚太地区的胃肠病学家进行了横断面调查，并与之前的澳大利亚调查进行了比较。问卷评估患者对组织学在IBD实践中的作用和应用的认识和态度。统计分析用于比较得分和确定预测因子。结果：共有来自12个国家的221名胃肠病学家参与问卷调查，其中澳大利亚77名（34.8%），完成调查的185名（83.7%）。平均知识得分为9.8±3.3分（51.6%）。国家间的平均得分无显著差异（P= 0.53）。IBD专科（P< 0.01）、博士学位（P= 0.02）、定期参加IBD多学科会议（P= 0.01）者得分较高。大多数受访者（90.7%）同意组织学在IBD中的重要性。虽然54.6%的澳大利亚人认为组织学的作用是既定的，但只有37.0%的亚洲受访者认为这一点相似（P= 0.02）。在内镜缓解的患者中，单独的组织学活动对治疗升级的影响最小，但实现组织-内镜联合缓解通常会导致治疗降级。结论：尽管亚太地区的胃肠病学家意识到组织学在IBD中的作用，但他们的知识仍然有限，其临床应用并未被广泛采用。有必要在IBD实践中推广标准化组织学评估的常规使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.40

自引率

10.20%

发文量

审稿时长

38 weeks

期刊介绍： Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.