Treatment of early-stage diabetic nephropathy with Siddha drug Sirupeelai Kudineer: A case series.

Abstract

Diabetic Nephropathy is one of the major microvascular complications of Diabetes Mellitus, which can be detected in the earlier stage by investigating urinary microalbumin excretion levels and estimating ACR and GFR. Early treatment can delay or prevent the progression of diabetic Nephropathy. Monoherbal Siddha formulation Sirupeelai Kudineer indicated for the complications of Diabetes Mellitus is selected for this Case study. The efficiency of the drug was assessed by measuring the change in renal function throughout the treatment period and the KD QOL assessment. Four patients presented with symptoms of Diabetic Nephropathy were treated with the monoherbal Siddha formulation Sirupeelai Kudineer. This series of four cases showed improvement in CKD QOL and some biochemical parameters. Blood urea was reduced in the four cases during medication. Serum creatinine levels mildly increased in three cases somewhere during the treatment period but decreased in all four cases after treatment. The estimated GFR also improved in three cases after treatment but mildly reduced in one patient. Symptomatic improvement was also observed in all the patients. Marked reduction in blood urea and serum creatinine levels after treatment shows the Nephroprotective action of the drug. The clinical and laboratory parameters observed among these four patients suggest that this drug may be used along with other hypoglycemic drugs to treat Diabetic Nephropathy.