Cefixime-Infused Green ZnO Nanoplatelets With Enhanced Biological Potential.

IF 2 3区工程技术 Q2 ANATOMY & MORPHOLOGY Microscopy Research and Technique Pub Date : 2024-11-30 DOI:10.1002/jemt.24719

Amna Munsaf, Muhammad Naeem Ahmed, Ihsan Ul Haq, Bilal Akram, Mahmoud A A Ibrahim

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Abstract

The escalating resistance to traditional antibiotics causes a significant hazard to public health, demanding innovative antimicrobial strategies. This study introduces cefixime-infused green-synthesized zinc oxide nanoplatelets (ZnO NPts) highlighting their enhanced biological potential. The successful formation of ZnO NPts and their subsequent infusion with cefixime were confirmed using various characterization techniques: UV-visible spectroscopy, Fourier transform infrared spectroscopy, x-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, and dynamic light scattering. Comparing cefixime-functionalized ZnO NPts with pure ZnO and cefixime alone, biological assessments revealed that the former exhibited stronger antifungal activity against the tested strains. Moreover, these NPts demonstrated the highest cytotoxicity in tests with Artemia salina larvae and pronounced antioxidant activity in TAC, TRP, and DPPH assays. These findings emphasize the significant potential of cefixime-infused ZnO NPts for various biomedical applications, offering enhanced antifungal, cytotoxic, and antioxidant properties.

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头孢昔肟注入的绿色ZnO纳米血小板具有增强的生物潜能。

对传统抗生素不断升级的耐药性对公共卫生造成重大危害，需要创新的抗微生物战略。本研究介绍了头孢昔肟注入的绿色合成氧化锌纳米血小板（ZnO NPts），突出了其增强的生物学潜力。利用紫外可见光谱、傅里叶变换红外光谱、x射线衍射、扫描电镜、透射电镜、能量色散光谱和动态光散射等多种表征技术，证实了ZnO npt的成功形成及其随后的头孢克肟输注。将头孢克肟功能化的氧化锌npt与纯氧化锌和单独使用头孢克肟的氧化锌npt进行比较，生物学评价显示前者对被试菌株具有更强的抗真菌活性。此外，这些NPts在盐蒿幼虫试验中表现出最高的细胞毒性，在TAC、TRP和DPPH试验中表现出明显的抗氧化活性。这些发现强调了头孢昔肟注入氧化锌npt在各种生物医学应用中的巨大潜力，具有增强的抗真菌、细胞毒性和抗氧化性能。

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来源期刊

Microscopy Research and Technique 医学-解剖学与形态学

CiteScore

5.30

自引率

20.00%

发文量

233

审稿时长

4.7 months

期刊介绍： Microscopy Research and Technique (MRT) publishes articles on all aspects of advanced microscopy original architecture and methodologies with applications in the biological, clinical, chemical, and materials sciences. Original basic and applied research as well as technical papers dealing with the various subsets of microscopy are encouraged. MRT is the right form for those developing new microscopy methods or using the microscope to answer key questions in basic and applied research.