Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-12-03 DOI:10.1038/s41522-024-00625-2

Yasmin Jaber, Avital Sarusi-Portuguez, Yasmin Netanely, Reem Naamneh, Shahd Yacoub, Or Saar, Nadeem Darawshi, Luba Eli-Berchoer, Hagit Shapiro, Eran Elinav, Asaf Wilensky, Avi-Hai Hovav

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Abstract

In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal barrier with significant health implications, exhibits intricate tissue architecture and likely contains specialized immunological regions. Through spatial transcriptomic analysis, this study reveals distinct immunological characteristics between the buccal and palate regions of the murine gingiva, impacting natural alveolar bone loss. The microbiota primarily affects gingival immunity in the buccal region. Additionally, a significant influence of the microbiota on the junctional epithelium facing the oral biofilm offers new insights into neutrophil recruitment. The microbiota also regulates the proliferation and barrier-sealing function of the gingival epithelium. This underscores the presence of immunological niches in the gingiva, with the microbiota differentially influencing them, highlighting the high complexity of this oral mucosal barrier.

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牙龈空间分析揭示了地理上的免疫变异是一种依赖微生物群和不依赖微生物群的方式。

在粘膜屏障中，组织细胞和白细胞协同形成支持宿主-微生物共生的专门生态位。了解这些障碍的空间组织对于阐明健康和疾病的潜在机制至关重要。牙龈是一种独特的粘膜屏障，具有重要的健康意义，具有复杂的组织结构，可能包含专门的免疫区域。通过空间转录组学分析，本研究揭示了小鼠牙龈颊区和腭区之间不同的免疫特性，影响自然牙槽骨丢失。微生物群主要影响口腔区域的牙龈免疫。此外，微生物群对口腔生物膜连接上皮的显著影响为中性粒细胞募集提供了新的见解。微生物群还调节牙龈上皮的增殖和屏障封闭功能。这强调了牙龈中免疫生态位的存在，微生物群对它们的影响是不同的，突出了这种口腔粘膜屏障的高度复杂性。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.