Thallium-201 single photon emission computed tomography for the differentiation of malignant versus non-malignant intracranial space-occupying lesions in developing countries

IF 2.5 4区医学 Q3 ONCOLOGY Current Problems in Cancer Pub Date : 2025-02-01 DOI:10.1016/j.currproblcancer.2024.101160

Mark Willy L. Mondia , Anisah Hayaminnah D. Alonto , Nicole Girlyn T. Pang , Francis Manuel L. Resma , Al Joseph R. Molina , John Kenneth V. Gacula , Arnel E. Pauco , Annabell E. Chua , Julette Marie F. Batara

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Abstract

Background

Thallium-201 single-photon emission computed tomography (TI-SPECT) imaging has been used historically to distinguish malignant cerebral neoplasms from infectious etiologies.

Objectives

Our study aims to conduct a retrospective study, review existing literature, and perform meta-analysis on the use of TI-SPECT to differentiate malignant from non-malignant nervous system lesions when other advanced imaging modalities are not available, such as in resource-limited setting.

Methods

A retrospective study on the use of TI-SPECT in differentiating malignant versus non-malignant nervous system lesions was conducted in two tertiary hospitals in the Philippines.

A systematic review of relevant studies regarding TI-SPECT for the central nervous system was also done. Meta-analysis was performed to generate pooled sensitivity and specificity.

Results

A total of 19 patients from 2 institutions were included in the analysis. Data from Philippine General Hospital showed a sensitivity of 83% (95% CI: 36%, 100%) and a specificity of 100% (95% CI: 16%, 100%), while St. Luke's Medical Center had a sensitivity of 100% (95% CI: 40%, 100%) and specificity of 100% (95% CI: 48%, 100%).

Thirty-two (32) articles were qualitatively described and 24 datasets were subjected to meta-analysis. Pooled sensitivity and specificity were 89% (95% CI: 81%-94%) and 81% (95% CI: 73%-87%), respectively with an area under the curve (AUC) for diagnostic accuracy of 92%.

Conclusion

TI-SPECT imaging may be a potential diagnostic tool to discriminate malignant from non-malignant nervous system lesions when advanced imaging modalities such as PET/ MRI are not available. Due to the heterogeneity of the population in the studies included in both the quantitative and qualitative analyses, further studies are needed to validate these findings.

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铊-201单光子发射计算机断层扫描鉴别发展中国家颅内恶性与非恶性占位性病变。

背景：铊-201单光子发射计算机断层扫描（TI-SPECT）成像历来被用于区分恶性脑肿瘤和感染性病因。目的：我们的研究旨在进行一项回顾性研究，回顾现有文献，并进行荟萃分析，在其他先进的成像方式不可用时，例如在资源有限的情况下，使用TI-SPECT来区分恶性和非恶性神经系统病变。方法：在菲律宾的两家三级医院对TI-SPECT在鉴别恶性与非恶性神经系统病变中的应用进行回顾性研究。本文还对中枢神经系统TI-SPECT的相关研究进行了系统综述。进行荟萃分析以产生敏感性和特异性。结果：2所医院共19例患者纳入分析。来自菲律宾总医院的数据显示敏感性为83% (95% CI: 36%, 100%)，特异性为100% (95% CI: 16%, 100%)，而圣卢克医疗中心的敏感性为100% (95% CI: 40%, 100%)，特异性为100% （95% CI: 48%, 100%）。对32篇文章进行了定性描述，并对24个数据集进行了meta分析。合并敏感性和特异性分别为89% （95% CI: 81%-94%）和81% (95% CI: 73%-87%)，诊断准确率的曲线下面积（AUC）为92%。结论：在PET/ MRI等先进的影像学手段不可用的情况下，TI-SPECT成像可能是鉴别神经系统恶性病变和非恶性病变的潜在诊断工具。由于在定量和定性分析中纳入的研究中人群的异质性，需要进一步的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cancer 医学-肿瘤学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

15 days

期刊介绍： Current Problems in Cancer seeks to promote and disseminate innovative, transformative, and impactful data on patient-oriented cancer research and clinical care. Specifically, the journal''s scope is focused on reporting the results of well-designed cancer studies that influence/alter practice or identify new directions in clinical cancer research. These studies can include novel therapeutic approaches, new strategies for early diagnosis, cancer clinical trials, and supportive care, among others. Papers that focus solely on laboratory-based or basic science research are discouraged. The journal''s format also allows, on occasion, for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering articles that present dynamic material that influences the oncology field.