[Analysis of RNA virus pathogenicity and development of novel prevention methods.]

Uirusu Pub Date : 2024-01-01 DOI:10.2222/jsv.74.57
Ryuta Uraki
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Abstract

In the first quarter of the 21st century, infectious diseases caused by RNA viruses such as SARS, pandemic influenza viruses, MERS, Zika virus, and SARS-CoV-2 have spread. When such emerging and re-emerging viruses occur and spread, it is important for public health to quickly analyze the characteristics of these viruses and develop preventive measures. We found that the Zika virus causes damage to the testes, leading to testicular atrophy; that a vaccine based on mosquito salivary gland proteins suppresses mosquito-borne Zika virus transmission/infection; that the pathogenicity of SARS-CoV-2 Omicron variants BA.2, BA.4, and BA.5 isolated from patients is comparable to that of Omicron BA.1; and that a strategy targeting regulatory T cells to enhance vaccine efficacy is effective. Here, I would like to briefly discuss these findings.

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RNA病毒致病性分析及新型预防方法的发展
21世纪头25年,SARS、大流行性流感病毒、MERS、寨卡病毒、SARS- cov -2等RNA病毒引发的传染病相继蔓延。当这些新出现和再出现的病毒发生和传播时,快速分析这些病毒的特征并制定预防措施对公共卫生至关重要。我们发现寨卡病毒会对睾丸造成损伤,导致睾丸萎缩;基于蚊子唾液腺蛋白的疫苗抑制蚊媒寨卡病毒传播/感染;从患者身上分离出的SARS-CoV-2组克隆ba2、ba4和ba5的致病性与组克隆ba1相当;并且针对调节性T细胞的策略能够有效地提高疫苗的效力。在这里,我想简要讨论一下这些发现。
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[Analysis of RNA virus pathogenicity and development of novel prevention methods.] [Current situations and future issues surrounding rabies in Japan and other countries]. [Data-Driven Research for Understanding and Predicting Viral Epidemics and Evolution]. [Characterization of SARS-CoV-2 variants using mini-gut organoids]. [Control of infectious virus shedding through mucosal antibody response following SARS-CoV-2 infection].
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