Association of subjective memory complaints with serum biomarkers of neurodegeneration and cognition: A population-based study

IF 4.5 2区医学 Q1 GERIATRICS & GERONTOLOGY Journal of the American Geriatrics Society Pub Date : 2024-12-03 DOI:10.1111/jgs.19300

Anisa Dhana MD, MSc, Charles S. DeCarli MD, Klodian Dhana MD, PhD, Pankaja Desai PhD, Kristin Krueger PhD, Denis A. Evans MD, Kumar B. Rajan PhD

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Abstract

Background

Subjective memory complaints (SMCs) refer to memory concerns reported by an individual, regardless of objective test impairment. We conducted a study to evaluate the association of SMCs with serum biomarkers of neurodegeneration, including neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total tau (t-tau). In addition, we evaluated the association of SMCs with the rate of cognitive decline.

Methods

This study included 1096 individuals participating in the Chicago Health and Aging Project, with data on SMCs, neurodegenerative biomarkers (NfL, GFAP, and t-tau), and global cognitive scores. The SMC score ranges from 0 to 8 and higher scores reflect more memory complaints. Linear regression models were developed to investigate the association of SMCs with serum biomarkers, adjusted by age, sex, race, education, and APOE e4. Linear mixed-effects models were used to examine the independent association of SMCs with cognitive decline in a multivariable model that was additionally adjusted by biomarkers of neurodegeneration.

Results

Of the 1096 individuals, 665 (60.7%) were female, 643 (58.7%) were African Americans, and the mean (SD) age at the baseline was 78.0 (5.8) years. Compared to individuals with fewer memory complaints (i.e., people in the first tertile of SMCs), those reporting more memory complaints (i.e., people in the third tertile of SMCs) had a 12.0% increase in serum concentrations of NfL and an 9.4% increase in GFAP. In addition, individuals reporting more memory complaints (i.e., those in the 3rd versus the 1st tertile of SMCs) had a faster rate of cognitive decline by 0.029 ( $β$ −0.029, 95% CI −0.046 to −0.013) standardized units per year.

Conclusions

Individuals who reported more memory complaints had higher levels of biomarkers of neurodegeneration and a faster rate of cognitive decline, suggesting that SMCs may be valuable for identifying people at high risk of cognitive impairment.

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主观记忆抱怨与神经变性和认知的血清生物标志物的关联：一项基于人群的研究。

背景：主观记忆抱怨（SMCs）是指个人报告的记忆问题，而不考虑客观测试障碍。我们进行了一项研究，以评估SMCs与神经退行性变的血清生物标志物的关系，包括神经丝轻链（NfL）、胶质纤维酸性蛋白（GFAP）和总tau （t-tau）。此外，我们评估了SMCs与认知能力下降速度的关系。方法：本研究纳入了1096名参加芝加哥健康与衰老项目的个体，收集了SMCs、神经退行性生物标志物（NfL、GFAP和t-tau）和整体认知评分的数据。SMC评分范围从0到8，分数越高反映对内存的抱怨越多。建立线性回归模型来研究SMCs与血清生物标志物的关系，并根据年龄、性别、种族、教育程度和APOE e4进行调整。使用线性混合效应模型，在多变量模型中检查SMCs与认知能力下降的独立关联，该模型还通过神经变性的生物标志物进行了调整。结果：在1096只个体中，665只(60.7%) were female, 643 (58.7%) were African Americans, and the mean (SD) age at the baseline was 78.0 (5.8) years. Compared to individuals with fewer memory complaints (i.e., people in the first tertile of SMCs), those reporting more memory complaints (i.e., people in the third tertile of SMCs) had a 12.0% increase in serum concentrations of NfL and an 9.4% increase in GFAP. In addition, individuals reporting more memory complaints (i.e., those in the 3rd versus the 1st tertile of SMCs) had a faster rate of cognitive decline by 0.029 ( β $$ \beta $$ -0.029, 95% CI -0.046 to -0.013) standardized units per year.Conclusions: Individuals who reported more memory complaints had higher levels of biomarkers of neurodegeneration and a faster rate of cognitive decline, suggesting that SMCs may be valuable for identifying people at high risk of cognitive impairment.

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来源期刊

Journal of the American Geriatrics Society 医学-老年医学

CiteScore

10.00

自引率

6.30%

发文量

504

审稿时长

3-6 weeks

期刊介绍： Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.