Anisa Dhana, Charles S DeCarli, Klodian Dhana, Pankaja Desai, Kristin Krueger, Denis A Evans, Kumar B Rajan
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引用次数: 0
Abstract
Background: Subjective memory complaints (SMCs) refer to memory concerns reported by an individual, regardless of objective test impairment. We conducted a study to evaluate the association of SMCs with serum biomarkers of neurodegeneration, including neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total tau (t-tau). In addition, we evaluated the association of SMCs with the rate of cognitive decline.
Methods: This study included 1096 individuals participating in the Chicago Health and Aging Project, with data on SMCs, neurodegenerative biomarkers (NfL, GFAP, and t-tau), and global cognitive scores. The SMC score ranges from 0 to 8 and higher scores reflect more memory complaints. Linear regression models were developed to investigate the association of SMCs with serum biomarkers, adjusted by age, sex, race, education, and APOE e4. Linear mixed-effects models were used to examine the independent association of SMCs with cognitive decline in a multivariable model that was additionally adjusted by biomarkers of neurodegeneration.
Results: Of the 1096 individuals, 665 (60.7%) were female, 643 (58.7%) were African Americans, and the mean (SD) age at the baseline was 78.0 (5.8) years. Compared to individuals with fewer memory complaints (i.e., people in the first tertile of SMCs), those reporting more memory complaints (i.e., people in the third tertile of SMCs) had a 12.0% increase in serum concentrations of NfL and an 9.4% increase in GFAP. In addition, individuals reporting more memory complaints (i.e., those in the 3rd versus the 1st tertile of SMCs) had a faster rate of cognitive decline by 0.029 ( -0.029, 95% CI -0.046 to -0.013) standardized units per year.
Conclusions: Individuals who reported more memory complaints had higher levels of biomarkers of neurodegeneration and a faster rate of cognitive decline, suggesting that SMCs may be valuable for identifying people at high risk of cognitive impairment.
背景：主观记忆抱怨（SMCs）是指个人报告的记忆问题，而不考虑客观测试障碍。我们进行了一项研究，以评估SMCs与神经退行性变的血清生物标志物的关系，包括神经丝轻链（NfL）、胶质纤维酸性蛋白（GFAP）和总tau （t-tau）。此外，我们评估了SMCs与认知能力下降速度的关系。方法：本研究纳入了1096名参加芝加哥健康与衰老项目的个体，收集了SMCs、神经退行性生物标志物（NfL、GFAP和t-tau）和整体认知评分的数据。SMC评分范围从0到8，分数越高反映对内存的抱怨越多。建立线性回归模型来研究SMCs与血清生物标志物的关系，并根据年龄、性别、种族、教育程度和APOE e4进行调整。使用线性混合效应模型，在多变量模型中检查SMCs与认知能力下降的独立关联，该模型还通过神经变性的生物标志物进行了调整。结果：在1096只个体中，665只(60.7%) were female, 643 (58.7%) were African Americans, and the mean (SD) age at the baseline was 78.0 (5.8) years. Compared to individuals with fewer memory complaints (i.e., people in the first tertile of SMCs), those reporting more memory complaints (i.e., people in the third tertile of SMCs) had a 12.0% increase in serum concentrations of NfL and an 9.4% increase in GFAP. In addition, individuals reporting more memory complaints (i.e., those in the 3rd versus the 1st tertile of SMCs) had a faster rate of cognitive decline by 0.029 ( β $$ \beta $$ -0.029, 95% CI -0.046 to -0.013) standardized units per year.Conclusions: Individuals who reported more memory complaints had higher levels of biomarkers of neurodegeneration and a faster rate of cognitive decline, suggesting that SMCs may be valuable for identifying people at high risk of cognitive impairment.
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