{"title":"Formulation Optimization of Metformin-Loaded Propyl Moringa Gum Beads","authors":"Atul Kaushik, Rimpy Pahwa, Rashmi Sharma, Vikramjeet Singh, Munish Ahuja","doi":"10.1007/s12247-024-09897-9","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of the present work was to optimize the formulation of extended-release, metformin-loaded ionically-gelled propyl <i>Moringa</i> gum beads.</p><h3>Method</h3><p>The metformin-loaded beads of propyl <i>Moringa</i> gum were prepared by ionotropic gelation method employing calcium chloride as a cross-linking agent. A three-factor three-level central composite experimental design was applied to obtain the optimized batch of beads with maximum %yield, drug entrapment and extended-release over 24 h. The optimized batch of beads was characterized by Fourier-transform infra-red spectroscopy, X-ray diffraction, scanning electron microscopy, swelling, and mucoadhesive behavior.</p><h3>Results</h3><p>The optimized batch of beads contains propyl <i>Moringa</i> gum – 5.916 (%w/v), calcium chloride – 11.779 (%w/v), and metformin – 25 mg. The % yield and drug entrapment efficiency of polymeric beads were found to be 124.31% and 62.83% respectively. X-ray diffraction patterns revealed the crystalline behavior of an optimized batch of metformin-loaded propyl <i>Moringa</i> gum beads. The scanning electron micrographs demonstrated the oblong-shaped and granular surface of polymeric beads. The optimized batch of polymeric beads exhibited pH dependent release with faster release in distilled water, pH 1.2, and 4.5 medium while sustained release at pH 6.8. The beads also showed good ex vivo mucoadhesive properties.</p><h3>Conclusion</h3><p>The optimized batch of ionically gelled propyl <i>Moringa</i> gum beads showed excellent potential for extended-release formulation of metformin. However, further in vivo studies are needed to explore its commercial potential.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"19 6","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-024-09897-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
The purpose of the present work was to optimize the formulation of extended-release, metformin-loaded ionically-gelled propyl Moringa gum beads.
Method
The metformin-loaded beads of propyl Moringa gum were prepared by ionotropic gelation method employing calcium chloride as a cross-linking agent. A three-factor three-level central composite experimental design was applied to obtain the optimized batch of beads with maximum %yield, drug entrapment and extended-release over 24 h. The optimized batch of beads was characterized by Fourier-transform infra-red spectroscopy, X-ray diffraction, scanning electron microscopy, swelling, and mucoadhesive behavior.
Results
The optimized batch of beads contains propyl Moringa gum – 5.916 (%w/v), calcium chloride – 11.779 (%w/v), and metformin – 25 mg. The % yield and drug entrapment efficiency of polymeric beads were found to be 124.31% and 62.83% respectively. X-ray diffraction patterns revealed the crystalline behavior of an optimized batch of metformin-loaded propyl Moringa gum beads. The scanning electron micrographs demonstrated the oblong-shaped and granular surface of polymeric beads. The optimized batch of polymeric beads exhibited pH dependent release with faster release in distilled water, pH 1.2, and 4.5 medium while sustained release at pH 6.8. The beads also showed good ex vivo mucoadhesive properties.
Conclusion
The optimized batch of ionically gelled propyl Moringa gum beads showed excellent potential for extended-release formulation of metformin. However, further in vivo studies are needed to explore its commercial potential.
期刊介绍:
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.