Olufunke D. Akin-Ajani, Noble Kuntworbe, Oluwatoyin A. Odeku
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引用次数: 0
Abstract
Purpose
In this study, coconut oil (liquid lipid) and shea butter (solid lipid) were used to formulate ciprofloxacin-loaded nanoparticles (nanostructured lipid carriers, NLC, solid lipid nanoparticles, SLN, or nanoemulsions, NE) which were then evaluated for pharmaceutical and antibacterial properties.
Methods
The nanoparticles were produced by hot homogenisation high-pressure technique with a combination of the solid and liquid lipids for the NLC, solid lipid alone for the SLN, and liquid lipid alone for the NE. The nanoparticles were characterised by size, polydispersity index (PDI), zeta potential, FTIR, drug entrapment efficiency, drug dissolution (in vitro) and release kinetics, antibacterial action, and stability.
Results
The nanoparticle sizes ranged from 157.0 ± 83.8 to 205.4 ± 95.6 nm, with PDI of 0.229–0.255, and zeta potential of -25.2 ± 5.6 to -45.3 ± 6.1mV. FTIR revealed no interaction between the drug and lipids. Drug entrapment was > 95.0%; only NLC had a t80 of < 45 min. Drug release kinetics followed the Korsmeyer-Peppas model showing a Super case II transport mechanism. The ranking of the antibacterial activity was SLN > NLC > NE against both Staphylococcus aureus and Salmonella typhi. Stability studies indicated that phase separation occurred, drug content was reduced (p > 0.05), while release kinetics and mechanism remained largely unchanged.
Conclusion
Coconut oil and shea butter lipids were effective for the formulation of ciprofloxacin-loaded nanoparticles, with the solid lipid nanoparticles and nanostructured lipid carriers demonstrating suitable pharmaceutical properties and antibacterial activity.
期刊介绍:
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.