S. O. Kushch, M. V. Goryaeva, Ya. V. Burgart, M. A. Ezhikova, M. I. Kodess, P. A. Slepukhin, V. I. Saloutin
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引用次数: 0
Abstract
The three-component reaction of polyfluoroalkyl-3-oxo esters with α,β-unsaturated aldehydes and 2-(aminomethyl)aniline afforded 8-(polyfluoro-1-hydroxyalkyl)-6,7,8,11-tetrahydro-9H-pyrido[2,1-b]quinazolin-9-ones upon heating; under mild conditions, this reaction gave bicyclic dihydroquinazoline intermediates, CF3 derivatives of which exist in the form of bases and their C2F5 analogues exist in the form of salts. The diastereomeric and tautomeric structures of the new heterocycles were studied by 1H, 19F, and 13C NMR spectroscopy, IR spectroscopy, and X-ray diffraction. A domino mechanism for their formation was proposed.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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