Ceapin-A7 suppresses the protective effects of Octreotide in human and bovine lung endothelial cells

IF 3.3 3区 生物学 Q3 CELL BIOLOGY Cell Stress & Chaperones Pub Date : 2025-02-01 DOI:10.1016/j.cstres.2024.12.001
Saikat Fakir, Madan Sigdel, Md Matiur Rahman Sarker, Joy T. Folahan, Nektarios Barabutis
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Abstract

Endothelial injury can be the cause and consequence of severe inflammation and injury. Synthetic somatostatin analogs—which suppress Growth Hormone—are clinically-approved drugs associated with anti-inflammatory activities. In the present study, we suggest that the protective activities of Octreotide in human and bovine endothelial cells are mitigated by Ceapin-A7, which is an activating transcription factor 6 inhibitor. To study endothelial function, we assessed protein expression levels of key cytoskeletal proteins, as well as paracellular permeability. To evaluate inflammation, we measured factors that promote vascular leak, as well as reactive oxygen species generation. Collectively, our study supports the involvement of activating transcription factor 6 in the protective effects of Octreotide in endothelial barrier function.
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Ceapin-A7抑制奥曲肽对人和牛肺内皮细胞的保护作用。
内皮损伤可能是严重炎症和损伤的原因和后果。合成的生长抑素类似物——抑制生长激素——是fda批准的具有抗炎活性的药物。在本研究中,我们认为奥曲肽对人和牛内皮细胞的保护作用被Ceapin-A7(一种激活转录因子6的抑制因子)所减弱。为了研究内皮功能,我们评估了关键细胞骨架蛋白的蛋白表达水平以及细胞旁通透性。为了评估炎症,我们测量了促进血管泄漏的因素,以及活性氧的产生。总的来说,我们的研究支持激活转录因子6参与奥曲肽对内皮屏障功能的保护作用。
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来源期刊
Cell Stress & Chaperones
Cell Stress & Chaperones 生物-细胞生物学
CiteScore
7.60
自引率
2.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.
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