Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.

IF 2.9 3区 医学 Q2 NEUROSCIENCES Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-02 DOI:10.1016/j.neuroscience.2024.11.076
Duan Li, Anthony G Hudetz
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Abstract

Complexity of neuronal firing patterns may serve as an indicator of sensory information processing across different states of consciousness. Recent studies have shown that spontaneous changes in brain states can occur during general anesthesia, which may influence neuronal complexity and the state of consciousness. In this study, we investigated how the firing patterns of cortical neurons, both at rest and during visual stimulation, are affected by spontaneously changing brain states under varying levels of anesthesia. Extracellular unit activity was measured in the primary visual cortex of unrestrained rats as the inhaled concentration of desflurane was incrementally reduced to 6%, 4%, 2%, and 0%. Using dimensionality reduction and density-based clustering on individual unit activities, we identified five distinct population states, which underwent dynamic transitions independent of the anesthetic level during both resting and stimulus conditions. One population state that occurred mainly in deep anesthesia exhibited a paradoxically increased number of active neurons and asynchronous spiking, suggesting a spontaneous reversal towards an awake-like condition. However, this was contradicted by the observation of low neuronal complexity in both spontaneous and stimulus-related spike activity, which more closely aligns with unconsciousness. Our findings reveal that transient neuronal states with distinct spiking patterns can emerge in visual cortex at constant anesthetic concentrations. The reduced complexity in states associated with deep anesthesia likely indicates a disruption of conscious sensory information processing.

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麻醉改变了大鼠视觉皮层自发和刺激相关的神经元放电模式的复杂性。
神经元放电模式的复杂性可以作为不同意识状态下感觉信息处理的一个指标。最近的研究表明,在全身麻醉时,大脑状态可能发生自发的变化,这可能会影响神经元的复杂性和意识状态。在这项研究中,我们研究了在不同程度的麻醉下,大脑状态的自发变化是如何影响皮层神经元在休息和视觉刺激时的放电模式的。当吸入地氟醚的浓度逐渐降低到6%、4%、2%和0%时,在未受约束的大鼠初级视觉皮层中测量细胞外单位活性。利用降维和基于密度的个体单元活动聚类,我们确定了五种不同的种群状态,它们在静息和刺激条件下都经历了独立于麻醉水平的动态转变。一种主要发生在深度麻醉下的群体状态表现出矛盾的增加的活跃神经元数量和异步尖峰,表明自发逆转到清醒状态。然而,这与自发和刺激相关的脉冲活动的低神经元复杂性的观察相矛盾,后者与无意识更紧密地联系在一起。我们的研究结果表明,在恒定的麻醉浓度下,视觉皮层可以出现具有不同尖峰模式的短暂神经元状态。与深度麻醉相关的状态的复杂性降低可能表明意识感觉信息处理的中断。
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来源期刊
Neuroscience
Neuroscience 医学-神经科学
CiteScore
6.20
自引率
0.00%
发文量
394
审稿时长
52 days
期刊介绍: Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.
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