Hong-Xia Zhang, Li-Gang Kou, Ya-Ru Gao, Qiong Jia, Yong-Qiang Wang
{"title":"Regiospecific Alkene Oxyamination via N‐Alkylation‐Hydroxylation‐Transesterification Cascades","authors":"Hong-Xia Zhang, Li-Gang Kou, Ya-Ru Gao, Qiong Jia, Yong-Qiang Wang","doi":"10.1002/adsc.202401365","DOIUrl":null,"url":null,"abstract":"An unprecedented cascade reaction of simple inactive alkenes, azo compounds and H2O to produce valuable poly‐substituted oxazolidinones is reported herein. The transformation possesses exclusive regioselectivity, and features mild reaction conditions and a broad substrate scope. Mechanistic studies indicated this transformation underwent a N‐alkylation‐hydroxylation‐transesterification cascade process. This research not only pushes the boundaries of the essential difunctionalization of alkenes but also exploits a new chemistry for azo compounds.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"79 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401365","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
An unprecedented cascade reaction of simple inactive alkenes, azo compounds and H2O to produce valuable poly‐substituted oxazolidinones is reported herein. The transformation possesses exclusive regioselectivity, and features mild reaction conditions and a broad substrate scope. Mechanistic studies indicated this transformation underwent a N‐alkylation‐hydroxylation‐transesterification cascade process. This research not only pushes the boundaries of the essential difunctionalization of alkenes but also exploits a new chemistry for azo compounds.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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