Milja Miettinen, Alex-Mikael Barkoff, Aino Nyqvist, Carita Savolainen-Kopra, Jenni Antikainen, Jussi Mertsola, Lauri Ivaska, Qiushui He
{"title":"Macrolide-resistant <i>Bordetella pertussis</i> strain identified during an ongoing epidemic, Finland, January to October 2024.","authors":"Milja Miettinen, Alex-Mikael Barkoff, Aino Nyqvist, Carita Savolainen-Kopra, Jenni Antikainen, Jussi Mertsola, Lauri Ivaska, Qiushui He","doi":"10.2807/1560-7917.ES.2024.29.49.2400765","DOIUrl":null,"url":null,"abstract":"<p><p>Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10-14 years. Of the 462 <i>Bordetella pertussis</i> isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 μg/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured <i>ptxP3</i> allele. The emergence of macrolide-resistant <i>B. pertussis</i> in Europe is worrisome and its rapid identification is important.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650481/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eurosurveillance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2807/1560-7917.ES.2024.29.49.2400765","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10-14 years. Of the 462 Bordetella pertussis isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 μg/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured ptxP3 allele. The emergence of macrolide-resistant B. pertussis in Europe is worrisome and its rapid identification is important.
期刊介绍：
Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.
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