Five-Year Incidence of Age-Related Macular Degeneration and Its Risk Factors in Adult Chinese Population: The Tongren Health Care Study.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY Translational Vision Science & Technology Pub Date : 2024-12-02 DOI:10.1167/tvst.13.12.10

Ying Cui, Jing Cui, Can Can Xue, Yu Mao, Jost B Jonas, Ya Xing Wang, Dong Ning Chen

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Abstract

Purpose: To examine the 5-year incidence of age-related macular degeneration (AMD) and its associated factors in an adult Chinese population.

Methods: The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital. Baseline examinations were performed from 2014 to 2015, with 5-year follow-up examinations conducted between 2019 and 2020. Fundus photographs were graded according to the Beckman Initiative guidelines.

Results: A total of 5658 participants with gradable photographs at both examinations were included in the study, comprising 58.0% women, with a mean age of 54.9 ± 11.0 years. The 5-year incidence of any, early, intermediate, and late AMD were 6.1% (95% confidence interval [CI], 5.5%-6.8%), 5.0% (95% CI, 4.4%-5.6%), 3.4% (95% CI, 2.9%-3.9%), and 0.3% (95% CI, 0.2%-0.4%), respectively. In multivariate analysis, incident early AMD was associated with older age (P < 0.001; odds ratio [OR], 1.04; 95% CI, 1.02-1.06), female sex (P = 0.011; OR, 1.42; 95% CI, 1.08-1.86), and a higher estimated glomerular filtration rate (P = 0.020; OR, 1.15; 95% CI, 1.02-1.30), whereas having diabetes was a protective factor (P = 0.019; OR, 0.61; 95% CI, 0.41-0.92). Incident intermediate AMD was associated with older age (P < 0.001; OR, 1.05; 95% CI, 1.04-1.07), a higher high-density lipoprotein cholesterol level (P < 0.001; OR, 1.97; 95% CI, 1.38-2.83) and a lower triglyceride level (P = 0.008; OR, 0.77; 95% CI, 0.64-0.93).

Conclusions: A higher estimated glomerular filtration rate level was a risk factor for incident early AMD. A higher high-density lipoprotein cholesterol level and lower triglyceride level were risk factors for incident intermediate AMD. This finding may point to the role of renal circulation and lipid metabolism in incident AMD.

Translational relevance: This community-based longitudinal study may provide a valuable understanding of AMD and its associated factors for targeted prevention and management strategies.

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中国成人年龄相关性黄斑变性5年发病率及其危险因素：铜仁保健研究

目的：探讨中国成人年龄相关性黄斑变性（AMD）的5年发病率及其相关因素。方法：铜仁卫生保健研究纳入在北京铜仁医院定期进行卫生保健检查的个体。2014 - 2015年进行基线检查，2019 - 2020年进行5年随访检查。眼底照片是根据贝克曼倡议指南分级的。结果：研究共纳入5658名参与者，两次检查照片均可分级，其中58.0%为女性，平均年龄54.9±11.0岁。任何、早期、中期和晚期AMD的5年发病率分别为6.1%（95%可信区间[CI]， 5.5%-6.8%）、5.0% （95% CI, 4.4%-5.6%）、3.4% （95% CI, 2.9%-3.9%）和0.3% （95% CI, 0.2%-0.4%）。在多变量分析中，早期AMD的发生与年龄相关(P < 0.001；优势比[OR]， 1.04；95% CI, 1.02-1.06)，女性(P = 0.011；或者,1.42;95% CI, 1.08-1.86)，估计肾小球滤过率较高(P = 0.020；或者,1.15;95% CI, 1.02-1.30)，而患有糖尿病是保护因素(P = 0.019；或者,0.61;95% ci, 0.41-0.92)。中期AMD的发生与年龄较大相关(P < 0.001；或者,1.05;95% CI, 1.04-1.07)，较高的高密度脂蛋白胆固醇水平(P < 0.001；或者,1.97;95% CI, 1.38-2.83)和较低的甘油三酯水平(P = 0.008；或者,0.77;95% ci, 0.64-0.93)。结论：较高的肾小球滤过率是发生早期AMD的危险因素。较高的高密度脂蛋白胆固醇水平和较低的甘油三酯水平是发生中度AMD的危险因素。这一发现可能表明肾循环和脂质代谢在AMD发病中的作用。转化相关性：这项以社区为基础的纵向研究可能为AMD及其相关因素提供有价值的理解，以制定有针对性的预防和管理策略。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.