{"title":"Association between <i>PRNCR1</i>, <i>PAX8AS1</i>, <i>MEG3</i>, and <i>PTENP1</i> gene polymorphisms and breast cancer risk.","authors":"Anoosha Asadi, Fatemeh Barati, Alireza Nakhaee, Danial Jahantigh, Seyed-Mehdi Hashemi, Mohsen Taheri, Gholamreza Bahari","doi":"10.1080/17410541.2024.2435800","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>In this study, we examined the polymorphisms of <i>PRNCR1</i> (rs13252298, rs1456315), <i>PAX8-AS1</i> (rs4848320) <i>MEG3</i> (rs7158663), <i>PTENP1</i> (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.</p><p><strong>Method: </strong>The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.</p><p><strong>Results & conclusion: </strong>The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC. The CT and TT genotype and Dominant and T allele of rs4848320 polymorphism is also a risk factor in the study population. The genotype AA, dominant, recessive and A allele of rs7158663 polymorphism and also CC genotype of rs7853346 polymorphism increase the risk of BC.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"373-383"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17410541.2024.2435800","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Aim: In this study, we examined the polymorphisms of PRNCR1 (rs13252298, rs1456315), PAX8-AS1 (rs4848320) MEG3 (rs7158663), PTENP1 (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.
Method: The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.
Results & conclusion: The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC. The CT and TT genotype and Dominant and T allele of rs4848320 polymorphism is also a risk factor in the study population. The genotype AA, dominant, recessive and A allele of rs7158663 polymorphism and also CC genotype of rs7853346 polymorphism increase the risk of BC.
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