Pouria Mazinani, Christian Cardillo, Peiman Mosaddegh
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引用次数: 0
Abstract
This study presents a comprehensive analysis of corneal biomechanics using shear wave elastography, leveraging finite element modeling to investigate the mechanical properties of corneal tissue. A 3D axis-symmetric corneal model was developed and subjected to various simulated conditions, including changes in intraocular pressure (IOP), boundary conditions, excitation pressure, and corneal curvature. The model incorporates hyper-viscoelastic material properties, allowing for an accurate representation of the cornea nonlinear behavior within physiological pressure ranges. Parametric studies were conducted to assess the sensitivity of shear wave velocity to variations in corneal biomechanical parameters. The results revealed that intrinsic material properties, particularly viscoelastic constants, significantly influence shear wave propagation, while external factors such as IOP and boundary conditions have minimal impact. The study also employed the Taguchi method for parametric optimization, identifying the first relaxation time as a critical factor affecting shear wave velocity. This work offers valuable insights into corneal biomechanics, with implications for improving diagnostic techniques and enhancing our understanding of corneal behavior under different physiological conditions. The findings support the potential application of shear wave elastography as a non-invasive tool for assessing corneal stiffness and advancing clinical practice in ophthalmology.
期刊介绍：
This interdisciplinary journal provides a forum for presenting new ideas in continuum and quasi-continuum modeling of systems with a large number of degrees of freedom and sufficient complexity to require thermodynamic closure. Major emphasis is placed on papers attempting to bridge the gap between discrete and continuum approaches as well as micro- and macro-scales, by means of homogenization, statistical averaging and other mathematical tools aimed at the judicial elimination of small time and length scales. The journal is particularly interested in contributions focusing on a simultaneous description of complex systems at several disparate scales. Papers presenting and explaining new experimental findings are highly encouraged. The journal welcomes numerical studies aimed at understanding the physical nature of the phenomena.
Potential subjects range from boiling and turbulence to plasticity and earthquakes. Studies of fluids and solids with nonlinear and non-local interactions, multiple fields and multi-scale responses, nontrivial dissipative properties and complex dynamics are expected to have a strong presence in the pages of the journal. An incomplete list of featured topics includes: active solids and liquids, nano-scale effects and molecular structure of materials, singularities in fluid and solid mechanics, polymers, elastomers and liquid crystals, rheology, cavitation and fracture, hysteresis and friction, mechanics of solid and liquid phase transformations, composite, porous and granular media, scaling in statics and dynamics, large scale processes and geomechanics, stochastic aspects of mechanics. The journal would also like to attract papers addressing the very foundations of thermodynamics and kinetics of continuum processes. Of special interest are contributions to the emerging areas of biophysics and biomechanics of cells, bones and tissues leading to new continuum and thermodynamical models.
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