Central Pathology in Spasmodic Dysphonia.

IF 2.5 4区 医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Journal of Voice Pub Date : 2024-12-05 DOI:10.1016/j.jvoice.2024.11.004
Kristen L Prijs, Caroline E Quindlen, Pelin Yuksel, Valerie Trollinger, Robert T Sataloff
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引用次数: 0

Abstract

Introduction: Spasmodic dysphonia a voice disorder characterized by loss of voluntary control of vocal fold movements during speech production. The pathophysiology is not well understood, but there have been proposed connections to areas within the brain such as the reticular formation surrounding the tractus solitarius, spinal trigeminal and ambiguus nuclei, inferior olive, and pyramids.

Objective: To determine whether there are differences on brain Magnetic resonance imaging (MRI) with and without gadolinium in patients affected by spasmodic dysphonia compared with those without to determine whether there is a central process involved in spasmodic dysphonia (SD) pathophysiology.

Methods: This was a retrospective review of patients from January 1995 through January 2023. Information from patient charts included age, sex, chief complaint, present and past medical/surgical history, social history, laryngeal Electromyography, and MRI scan results. MRI of the head had to have been performed with and without gadolinium. MRI scan reports were evaluated for the presence or absence of hyperintensities and or hypointensities on T1, T2, or Fluid-attenuated inversion recovery within specific regions of the brain. This information was compared between groups to determine whether SD patients have an increased prevalence of Central nervous system pathology and to determine the location of pathology. Data were analyzed for relationships and significance.

Results: Seventy-two SD patients were included. Most study patients had adductor SD, with a 2.6:1 ratio of adductor to abductor. The SD patients were age and sex matched with patients who had otologic and laryngologic complaints. MRI abnormalities were found in the periventricular white matter, cerebral white matter, and frontal white matter.

Conclusions: There are no significant differences in the locations of hyperintensities and hypointensities on MRI of the brain with and without gadolinium in spasmodic dysphonia patients when compared to otologic and laryngologic controls.

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痉挛性发声障碍的中心病理。
简介:痉挛性发声障碍是一种语音障碍,其特征是在说话过程中失去对声带运动的自主控制。病理生理学尚不清楚,但已提出与大脑内的网状结构,如孤束周围的网状结构,脊髓三叉核和模棱两可核,下橄榄核和锥体有关。目的:探讨痉挛性发声障碍患者加、不加钆的脑磁共振成像(MRI)与不加钆的脑磁共振成像(MRI)是否有差异,以确定痉挛性发声障碍(SD)病理生理是否有中枢过程参与。方法:对1995年1月至2023年1月的患者进行回顾性研究。来自患者病历的信息包括年龄、性别、主诉、现在和过去的病史/手术史、社会史、喉部肌电图和MRI扫描结果。头部的核磁共振成像必须在使用或不使用钆的情况下进行。评估MRI扫描报告在大脑特定区域T1、T2或液体衰减反转恢复时是否存在高或低信号。将这些信息在组间进行比较,以确定SD患者是否有增加的中枢神经系统病理患病率,并确定病理的位置。对数据进行相关性和显著性分析。结果:纳入SD患者72例。大多数研究患者有内收肌SD,内收肌与外展肌的比例为2.6:1。SD患者的年龄和性别与有耳科和喉科主诉的患者相匹配。MRI发现脑室周围白质、脑白质和额白质异常。结论:与耳喉对照相比,加钆和不加钆的痉挛性发声障碍患者在脑部MRI上的高、低信号位置无显著差异。
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来源期刊
Journal of Voice
Journal of Voice 医学-耳鼻喉科学
CiteScore
4.00
自引率
13.60%
发文量
395
审稿时长
59 days
期刊介绍: The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.
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