Relationship of HbA1c with Mean Platelet Volume and Leucocyte Count in Patients with Type 2 Diabetes Mellitus.

Abstract

Objective: To determine the relationship between mean platelet volume (MPV), leucocyte count, and HbA1c levels in patients with type 2 diabetes mellitus (DM).

Study design: Observational study. Place and Duration of the Study: Bahcesehir Family Healthcare Centre (FHC), Adana, Turkiye, from January 2023 to 2024.

Methodology: This study included 101 controls and 106 patients with Type 2 diabetes mellitus (DM). Age, gender, body mass index (BMI), duration of diabetes, smoking, type of diabetic medication, and presence of chronic diseases were all assessed in relation to the patients. Analysis of leucocyte count, MPV, and HbA1c was conducted retrospectively. IBM SPSS version 25.0 was utilised for the statistical analysis, with p <0.05 being considered as the significance threshold.

Results: The DM group exhibited significantly higher levels of HbA1c (7.8 ± 1.5%), MPV (9.2 ± 1.3 fL), and leucocyte count (7.1 ± 1.8 x10^3/µL) in comparison to the control group (p <0.001). There was a positive and statistically significant association found between the leucocyte count, MPV, and HbA1c. In the control group, there was no significant link onserved.

Conclusion: In patients with Type 2 DM, a favourable connection between HbA1c, MPV, and leucocyte count was observed. These results point to a higher risk of thrombosis and inflammation in DM patients. Patients with HbA1c values above 7 showed increased leucocyte counts and MPV, which indicated that these patients were at a higher risk of vascular problems. Leucocyte counts and MPV may serve as useful biomarkers to gauge the likelihood of vascular problems in DM.

Key words: Type 2 diabetes mellitus, HbA1c, Mean platelet volume, Leucocyte count, Inflammation, Vascular complications.