Saba Saleem Safdar, Khadija Qamar, Aqsa Zahid, Muhammad Fahad Atta, Muhammad Rizwan Bashir Kiani, Muhammad Sabir
{"title":"Impact of Chronic Noise Stress on Thyroid Health: A Comparative Histomorphological and Endocrine Study in Adult Male and Female Rats.","authors":"Saba Saleem Safdar, Khadija Qamar, Aqsa Zahid, Muhammad Fahad Atta, Muhammad Rizwan Bashir Kiani, Muhammad Sabir","doi":"10.29271/jcpsp.2024.12.1406","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare the effect of varying durations of noise exposure on the histomorphological and endocrine profile of the thyroid gland in male and female adult rats.</p><p><strong>Study design: </strong>An experimental study. Place and Duration of the Study: Department of Anatomy, Army Medical College, Rawalpindi / NUMS, from January to December 2020.</p><p><strong>Methodology: </strong>Thirty Sprague-Dawley rats (15 males and 15 females) were divided into three groups each having 10 rats with equal male- to-female ratio. Group A was the control group. Group B and Group C were exposed to 100 dB noise for 4 hours daily and 100 dB noise for 6 hours daily for 4 months, respectively. Thyroid histomorphological parameters such as follicular epithelial cells' height, follicular diameter, and thyroid stimulating hormone (TSH) levels were evaluated at the end of the study.</p><p><strong>Results: </strong>Both male and female rats exposed to noise stress exhibited reduced follicular diameter (p <0.001) and increased epithelial cells' height (p <0.001) as compared to the control group. The experimental groups showed significantly higher TSH levels compared to the control group (p <0.001) among female rats, while no significant difference was observed among male rats (p 0.47). No significant differences in histological and serum parameters were noted between the experimental groups (Group B and C).</p><p><strong>Conclusion: </strong>Chronic noise exposure induces hyperactivity of thyroid follicles in both male and female adult rats as evidenced by the thyroid histology, whereas only female rats showed raised TSH levels, suggesting a potential disruption in the hypothalamic-pituitary-thyroid axis.</p><p><strong>Key words: </strong>Thyroid gland, Chronic noise stress, Follicular epithelial cells, Thyroid stimulating hormone, Thyroid follicles.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"34 12","pages":"1406-1410"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29271/jcpsp.2024.12.1406","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Objective: To compare the effect of varying durations of noise exposure on the histomorphological and endocrine profile of the thyroid gland in male and female adult rats.
Study design: An experimental study. Place and Duration of the Study: Department of Anatomy, Army Medical College, Rawalpindi / NUMS, from January to December 2020.
Methodology: Thirty Sprague-Dawley rats (15 males and 15 females) were divided into three groups each having 10 rats with equal male- to-female ratio. Group A was the control group. Group B and Group C were exposed to 100 dB noise for 4 hours daily and 100 dB noise for 6 hours daily for 4 months, respectively. Thyroid histomorphological parameters such as follicular epithelial cells' height, follicular diameter, and thyroid stimulating hormone (TSH) levels were evaluated at the end of the study.
Results: Both male and female rats exposed to noise stress exhibited reduced follicular diameter (p <0.001) and increased epithelial cells' height (p <0.001) as compared to the control group. The experimental groups showed significantly higher TSH levels compared to the control group (p <0.001) among female rats, while no significant difference was observed among male rats (p 0.47). No significant differences in histological and serum parameters were noted between the experimental groups (Group B and C).
Conclusion: Chronic noise exposure induces hyperactivity of thyroid follicles in both male and female adult rats as evidenced by the thyroid histology, whereas only female rats showed raised TSH levels, suggesting a potential disruption in the hypothalamic-pituitary-thyroid axis.
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