Spatial biology captures the effects of neoadjuvant chemo-immunotherapy in lung cancer

IF 31.7 1区 生物学 Q1 GENETICS & HEREDITY Nature genetics Pub Date : 2024-12-10 DOI:10.1038/s41588-024-01992-4
Jonathan H. Chen, Justin F. Gainor
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Abstract

PD-1 pathway blockade in combination with chemotherapy has emerged as a treatment paradigm for patients with resectable lung cancer, but insights into predictive biomarkers and mechanisms of immune responses are lacking. A study uses spatial transcriptomic methods to identify patterns within the tumor microenvironment associated with response.

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空间生物学捕捉新辅助化疗免疫治疗在肺癌中的作用
PD-1通路阻断联合化疗已成为可切除肺癌患者的治疗范例,但缺乏对预测性生物标志物和免疫反应机制的了解。一项研究使用空间转录组学方法来确定肿瘤微环境中与反应相关的模式。
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来源期刊
Nature genetics
Nature genetics 生物-遗传学
CiteScore
43.00
自引率
2.60%
发文量
241
审稿时长
3 months
期刊介绍: Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution
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