Clinicopathological significance of sulfite oxidase expression in surgically resected lung adenocarcinoma.

IF 1.2 4区医学 Q3 PATHOLOGY Medical Molecular Morphology Pub Date : 2024-12-09 DOI:10.1007/s00795-024-00413-z

Saeko Tokisawa, Reiichiro Kondo, Masamichi Nakayama, Sachiko Ogasawara, Kenta Murotani, Masahiro Mitsuoka, Tomoaki Hoshino, Hirohisa Yano, Jun Akiba

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Abstract

Aim: The coenzyme sulfite oxidase (SUOX), located in mitochondria, plays a role in redox and metabolism. Its expression has been associated with cancer progression and prognosis. Lung cancer has a high incidence rate and poor prognosis. We aim to clarify its expression in lung adenocarcinomas and investigated the utility of SUOX expression as a recurrence factor in operable lung adenocarcinoma.

Methods: We used 60 formalin-fixed paraffin-embedded samples of operable primary lung adenocarcinoma between 2017 and 2018 to immunohistochemically assess SUOX expression levels. Patients were classified into a high or low SUOX expression group, and the associations of SUOX expression with clinicopathological findings and recurrence were analyzed.

Results: We revealed that high SUOX expression was significantly (p < 0.05) associated with sex, low Brinkman index, histological type, histological grade and positive for epidermal growth factor receptor (EGFR) mutation. High SUOX expression (HR = 10.218, 95% CI 1.758‒59.376, p = 0.0096) and pathological Stage (HR = 7.538, 95% CI 1.95‒29.14, p = 0.0034) were independently associated with relapse free survival.

Conclusion: High SUOX expression may be a new indicator of recurrence risk in surgically resected lung adenocarcinomas.

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亚硫酸盐氧化酶在肺腺癌手术切除组织中表达的临床病理意义。

目的：辅酶亚硫酸盐氧化酶（SUOX）位于线粒体中，在氧化还原和代谢过程中起重要作用。它的表达与癌症的进展和预后有关。肺癌发病率高，预后差。我们的目的是阐明其在肺腺癌中的表达，并研究SUOX表达作为可手术肺腺癌复发因子的效用。方法：选取2017 - 2018年可手术原发性肺腺癌60例经福尔马林固定石蜡包埋标本，免疫组化检测SUOX表达水平。将患者分为SUOX高表达组和低表达组，分析SUOX表达与临床病理表现及复发的关系。结论：高SUOX表达可能是手术切除肺腺癌复发风险的新指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.