[Prognosis of unipolar depression].

Abstract

Depression, a severe illness with variable outcomes, requires prompt intervention to mitigate the risk of exacerbation and suicide. This review finds that psychopharmacological treatment is critical in severe cases. In mild cases, medication's side effects frequently outweigh the benefits. Prioritising non-pharmacological strategies, especially psychotherapy, is essential for mild to moderate depression. Given its recurrent nature and the risk of lasting cognitive decline, maintenance treatment is vital to avert relapse, particularly for those with a history of multiple episodes.