Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review.

Esra Kasapgil, Manuela Garay-Sarmiento, César Rodriguez-Emmenegger
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Abstract

Biomaterial-associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in-depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial-eluting biomaterials, contact-killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology.

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对抗生物材料相关感染的先进抗菌策略:综述
生物材料相关感染(BAIs)是现代医学技术面临的重大挑战,是主要的术后并发症和种植体失败的主要原因。这些感染严重危及患者健康,导致住院时间延长,发病率和死亡率增加,治疗费用增加。本文综述了生物材料表面细菌粘附和生物膜形成的机制,并对目前预防BAIs的抗菌策略进行了深入分析。我们探索了抗菌洗脱生物材料、接触杀灭表面和防污涂层,重点介绍了防污聚合物刷在医疗器械上的应用。本文还讨论了多功能抗菌生物材料的最新进展,这些生物材料集成了多种机制,对BAIs具有良好的保护作用。通过对这些策略的优缺点进行评价,旨在指导高效、生物相容性好的抗菌生物材料的设计和开发。我们强调潜在的设计路线,促进从实验室研究过渡到临床应用。此外,我们还提供了合成生物学作为对抗抗菌素耐药性的新方法的潜力的见解。本综述旨在启发未来的研究和创新,最终改善患者的治疗效果和推进医疗设备技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
17.60
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