Cation Enrichment Effect Modulated Nafion/Graphene Field-Effect Transistor for Ultrasensitive RNA Detection

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Letters Pub Date : 2024-12-11 DOI:10.1021/acs.nanolett.4c03989

Heqi Ma, Shuo Chen, Xinhao Zhang, Tianyu Sun, Panpan Huo, Xiangyong Cui, Baoyuan Man, Cheng Yang, Dongmei Wei

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Abstract

The graphene field-effect transistor (GFET) biosensor serves as a foundational platform for detecting biomolecules, offering high conductivity, label-free operation, and easy integration. These features have garnered significant attention in biomarker detection. However, the presence of free cations in solution often leads to electrostatic shielding of negatively charged biomolecules, reducing GFET detection sensitivity (LOD ≥ 1 fM). Additionally, the limited capacitance change in GFET restricts its use as a response signal. This study introduces a cation enrichment electric field modulation strategy (CEEFMS) to enhance capacitance and Dirac voltage response during detection. The cation-enriched rough Nafion/graphene FET (CENG-FET) achieves RNA detection at the aM level. Utilizing total capacitance change and Dirac voltage shift as response signals, the CENG-FET demonstrates a wide linear range from 1 aM to 1 pM. These findings advance dual-signal detection strategies, reducing accidental inaccuracies in biomolecular sensing and paving the way for further research.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.