Choroidal and Choriocapillaris OCT-A Analysis in Patients Affected by Active Central Serous Chorioretinopathy.

IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Translational Vision Science & Technology Pub Date : 2024-12-02 DOI:10.1167/tvst.13.12.14
Maria Ludovica Ruggeri, Marzia Passamonti, Alberto Quarta, Olgers Koci, Annamaria Porreca, Marta Di Nicola, Lucio Zeppa, Rodolfo Mastropasqua, Lisa Toto
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Abstract

Purpose: To analyze choroidal and choriocapillaris changes in eyes affected by active unilateral central serous chorioretinopathy (CSC).

Methods: A total of 17 eyes suffering from naïve CSC were enrolled. In addition, 17 healthy fellow eyes were analyzed, and 10 eyes were enrolled as controls. Main outcome measures were choroidal vascularity index (CVI), best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and pigment epithelial detachment (PED) presence and maximum height (PED-MH). In addition, choriocapillaris and choroidal flow analysis in the two concentric areas surrounding the fovea were analyzed.

Results: CCT was higher in affected eyes than healthy ones (P = 0.007). CVI was significantly higher in affected eyes (P = 0.027) and in fellow eyes (P = 0.027) compared to healthy. The choriocapillaris analysis showed interesting results in the first ring, with statistically significant differences between diseased eyes and fellow eyes and in diseased eyes compared to healthy ones. Besides, in the second ring analysis a lower flow in choriocapillaris was found in diseased eyes compared with healthy (P = 0.019). The choroidal flow analysis showed lower flow in affected eyes in the first and second ring when comparing diseased eyes with healthy controls (P = 0.006).

Conclusions: Choroidal and choriocapillaris flow abnormalities occur in both eyes affected by CSC and fellow eyes with different trends depending on the area of study reinforcing the key role of choroid and choriocapillaris in the pathogenesis of disease.

Translational relevance: Understanding choroidal and choriocapillaris flow abnormalities in CSC eyes could give us new biomarkers able to monitor disease.

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活动性中枢性浆液性脉络膜视网膜病变患者脉络膜和绒毛膜毛细血管OCT-A分析。
目的:分析单侧中枢性浆液性脉络膜视网膜病变(CSC)对眼部脉络膜和绒毛膜毛细血管的影响。方法:选取naïve CSC患者17只眼。此外,还分析了17只健康的眼睛,并将10只眼睛作为对照。主要结局指标为脉络膜血管指数(CVI)、最佳矫正视力(BCVA)、黄斑中央厚度(CMT)、中央窝下脉络膜厚度(SFCT)、色素上皮脱离(PED)的存在和最大高度(PED- mh)。此外,分析了中央窝周围两个同心区域的脉络膜毛细血管和脉络膜血流。结果:患眼CCT高于健康眼(P = 0.007)。与健康眼相比,病变眼的CVI (P = 0.027)和其他眼(P = 0.027)均显著升高。绒毛膜毛细血管分析在第一环显示出有趣的结果,患病眼睛和正常眼睛之间以及患病眼睛和健康眼睛之间存在统计学上的显著差异。此外,在第二环分析中,患病眼的绒毛膜毛细血管流量较健康眼低(P = 0.019)。脉络膜流量分析显示,患病眼与健康对照组相比,第一和第二环的脉络膜流量较低(P = 0.006)。结论:CSC患者双眼及伴眼均发生脉络膜和绒毛膜毛细血管血流异常,且随研究区域的不同有不同的趋势,强化了脉络膜和绒毛膜毛细血管在疾病发病机制中的关键作用。翻译相关性:了解CSC眼的脉络膜和绒毛膜毛细血管血流异常可以为我们提供能够监测疾病的新生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Translational Vision Science & Technology
Translational Vision Science & Technology Engineering-Biomedical Engineering
CiteScore
5.70
自引率
3.30%
发文量
346
审稿时长
25 weeks
期刊介绍: Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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