NIR-II Ratiometric Optical Theranostic Capsule for In Situ Diagnosis and Precise Therapy of Intestinal Inflammation

IF 15.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY ACS Nano Pub Date : 2024-12-11 DOI:10.1021/acsnano.4c12894
Kang Zhu, Xing Liu, Liping Fu, Jingjing Cao, Ying Wu, Chunxiang Mo, Jing Mu, Jibin Song
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Abstract

Capsules were widely used in clinical settings for the oral delivery of various drugs, although it remains challenging to trace real-time drug release behavior and adjust dosages based on the therapeutic effect. To address these issues, we developed theranostic capsules that loaded two kinds of fluorescence nanoparticles, H2O2-responsive Janus Ag/Ag2S nanoparticles (Ag/Ag2S JNPs) and the downconversion nanoparticles (DCNPs), and the dexamethasone (Dex) drug. The Ag/Ag2S JNPs exhibit a highly sensitive fluorescence (FL) signal at 1250 nm in response to H2O2, while the FL signal from the DCNPs at 1550 nm remains stable under physiological conditions. The ratio of these two FL signals formed the ratiometric FL signal, which shows correlation with the H2O2 concentration with a detection limit of 1.7 μM. Moreover, the capsules can be precisely delivered into the intestine, where they release the JNPs and DCNPs simultaneously. The H2O2-triggered ratiometric FL signals and images can diagnose inflammation and indicate its location. Meanwhile, the encapsulated Dex is released in the disease region, with ratiometric imaging allowing for real-time tracking of therapeutic efficacy and providing guidance for ongoing treatment. The theranostic capsule system provides an approach for quantitative detection of disease biomarkers and further localized release of therapeutics, thereby avoiding overdose and reducing side effects.

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NIR-II比率光学治疗胶囊用于肠道炎症的原位诊断和精确治疗
胶囊在临床上广泛用于各种药物的口服给药,但实时追踪药物释放行为和根据治疗效果调整剂量仍然具有挑战性。为了解决这些问题,我们开发了装载两种荧光纳米颗粒的治疗胶囊,即h2o2响应Janus Ag/Ag2S纳米颗粒(Ag/Ag2S JNPs)和下转换纳米颗粒(DCNPs),以及地塞米松(Dex)药物。Ag/Ag2S JNPs在1250 nm处对H2O2表现出高度敏感的荧光信号,而DCNPs在1550 nm处的荧光信号在生理条件下保持稳定。两种荧光信号的比值形成比值荧光信号,该荧光信号与H2O2浓度相关,检测限为1.7 μM。此外,这种胶囊可以精确地进入肠道,在那里它们同时释放JNPs和DCNPs。h2o2触发的比例FL信号和图像可以诊断炎症并指示其位置。同时,包封的Dex在疾病区域释放,比例成像允许实时跟踪治疗效果,并为持续治疗提供指导。该治疗胶囊系统提供了一种定量检测疾病生物标志物和进一步局部释放治疗药物的方法,从而避免过量和减少副作用。
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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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