Non-contact sensor module for rapid detection of extravasation during intravenous drug administration

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2024-12-13 DOI:10.1007/s10544-024-00730-1

Muhammad Salman Al Farisi, June Okazaki, Yoshihiro Hasegawa, Miyoko Matsushima, Tsutomu Kawabe, Mitsuhiro Shikida

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Abstract

Intravenous drug administration delivers medication directly into the bloodstream, providing rapid and controlled effects, making it highly beneficial for emergencies or when immediate drug action is required. However, several risks are associated with intravenous drug administration, including infiltration and extravasation, which can lead to serious complications due to the rapid absorption of medication to the surrounding tissues. To prevent complications, here we proposed a non-contact sensor module to rapidly detect such events. The system does not interfere with the human skin, nor contaminating the flowing medication since only biocompatible materials are exposed to the liquid. The proposed sensor module was assembled as a flow channel with flow rate and pressure sensing functions. The flow rate sensing was realized using a micromachined thermal flow sensor fabricated on a thin polyimide film, while the pressure sensing was realized using a diaphragm structure and a MEMS pressure sensor. Basic characteristics of each function was evaluated and a proof of concept experiment demonstrated a rapid detection of infiltration/extravasation within a few s. Measurement of leaked fluid volume during the event was also demonstrated.

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非接触式传感器模块，用于快速检测静脉给药过程中的外渗

静脉给药将药物直接输送到血液中，提供快速和可控的效果，使其在紧急情况或需要立即药物作用时非常有益。然而，静脉给药存在一些风险，包括浸润和外渗，由于药物被周围组织迅速吸收，可能导致严重的并发症。为了防止并发症，我们提出了一种非接触式传感器模块来快速检测此类事件。该系统不会干扰人体皮肤，也不会污染流动的药物，因为只有生物相容性材料暴露在液体中。所提出的传感器模块被组装成一个具有流量和压力传感功能的通道。流量传感采用聚酰亚胺薄膜微机械热流量传感器，压力传感采用膜片结构和MEMS压力传感器。评估了每个功能的基本特征，概念验证实验证明了在几秒内快速检测渗透/外渗。还演示了事件期间泄漏流体体积的测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.