Interictal epileptiform discharge-related BOLD responses in the default mode network and subcortical regions

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-02-01 DOI:10.1016/j.clinph.2024.11.017

Satoru Ikemoto , Nicolás von Ellenrieder , Jean Gotman

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Abstract

Objective

To examine the blood oxygen level-dependent (BOLD) responses in the default mode network (DMN) and subcortical regions in relation to epileptic events in scalp EEG and intracranial EEG (iEEG).

Methods

We retrospectively compared BOLD responses in the DMN and subcortical regions to interictal epileptiform discharge (IED) characteristics of the scalp and iEEG in consecutive patients with focal epilepsy. All voxels were used as the denominator to assess the positive and negative BOLD ratios in each region, and the percentage of voxels with significant activation or deactivation was assessed.

Results

Seventy-one EEG-fMRI studies were included. The widespread IED group showed a higher negative BOLD ratio in the DMN than did the focal IED group. Spike and ripple spreads in iEEG positively correlated with a positive BOLD ratio in the DMN and subcortical regions and a negative BOLD ratio in the DMN. Fast ripple spread showed no correlation with the BOLD ratio in any region.

Conclusions

IEDs affect local regions, as well as distant neocortical (DMN) and subcortical regions, depending on their localization and characteristics.

Significance

Our findings showed both positive and negative IED-related BOLD responses in subcortical regions and new evidence of network dysfunction related to focal epileptic activity.

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默认模式网络和皮层下区域中癫痫样放电相关的间歇期BOLD反应。

目的：探讨脑电和颅内脑电（iEEG）中脑默认模式网络（DMN）和皮层下区域的血氧水平依赖（BOLD）反应与癫痫事件的关系。方法：我们回顾性比较了连续局灶性癫痫患者的DMN和皮层下区域的BOLD对头皮和iEEG间期癫痫样放电（IED）特征的反应。所有体素被用作分母来评估每个区域的正、负BOLD比率，并评估显著激活或失活的体素的百分比。结果：纳入71项EEG-fMRI研究。广泛性IED组DMN的BOLD负比值高于局灶性IED组。iEEG的Spike和ripple扩散与DMN和皮层下区域的阳性BOLD比率和DMN的负BOLD比率呈正相关。在任何区域，快速纹波扩散与BOLD比率均无相关性。结论：ied影响局部区域，以及远端新皮层（DMN）和皮层下区域，这取决于其定位和特征。意义：我们的研究结果显示，皮层下区域与ied相关的BOLD反应呈阳性和阴性，这是与局灶性癫痫活动相关的网络功能障碍的新证据。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.