Lars Fabian Prinz, Roland Tillmann Ullrich, Markus Martin Chmielewski
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引用次数: 0
Abstract
In an article published in Cell in September 2024, Baldwin and colleagues present a bone marrow stromal cell (BMSC) based mitochondrial transfer platform to combat mitochondrial dysfunction or scarcity in human T cells ex-vivo.1 This thorough and methodically diverse investigation results in a promising technology at a time when adoptive T cell therapies seem to run against a wall of T cell exhaustion and dysfunction in treatments targeting solid tumors.2
鲍德温及其同事在 2024 年 9 月发表在《细胞》（Cell）杂志上的一篇文章中，介绍了一种基于骨髓基质细胞（BMSC）的线粒体转移平台，用于在体外对抗人类 T 细胞的线粒体功能障碍或稀缺性。1 在针对实体瘤的治疗中，当采用 T 细胞疗法似乎遇到 T 细胞衰竭和功能障碍时，这项全面而方法多样的研究产生了一种前景广阔的技术。
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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