Role of Systemic Immune-Inflammation Index, Systemic Inflammation Response Index, and Pan-Immune Inflammation Value in the Prediction of Preeclampsia: A Retrospective Cohort Study

IF 2.4 3区医学 Q3 IMMUNOLOGY American Journal of Reproductive Immunology Pub Date : 2024-12-13 DOI:10.1111/aji.70029

Sadullah Özkan, Murat Levent Dereli, Fahri Burcin Firatligil, Dilara Kurt, Ahmet Kurt, Serap Topkara Sucu, Sadun Sucu, Sevki Celen, Yaprak Engin-Ustun

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Abstract

Objective

The aim of the study was to investigate the role of systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) calculated from first trimester complete blood count (CBC) in predicting preeclampsia without (PE) and with severe features (PE-SF).

Methods

This retrospective cohort study included 126 women with PE, 126 women with PE-SF, and 126 women with healthy, normotensive pregnancies delivered at a large tertiary referral hospital between 2018 and 2022. The main outcome measures were SII, SIRI, and PIV.

Results

SII scores differed significantly between the control versus PE and control versus PE-SF groups, while SIRI scores showed a significant difference between the control versus PE and PE versus PE-SF groups. However, the PIV values showed a significant difference in all three groups. According to the receiver operating characteristic analysis performed for the discriminatory power of SII, SIRI, and PIV, the area under the curve (AUC) values were 0.801, 0.609, and 0.774 for the prediction of PE and 0.535, 0.701, and 0751 for the prediction of PE-SF, respectively. An SII with a cutoff value of > 620.59×10³/µL (sensitivity 81%, specificity 67%) and an SIRI with a cutoff value of > 0.94×10³/µL (sensitivity 74%, specificity 69%) had the highest discriminatory power for the prediction of PE and PE-SF, respectively.

Conclusion

Our results suggest an association between high SII, PIV, and SIRI results and an increased risk of future PE and could be used as a first trimester screening test to improve decision making in the prediction of PE.

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系统性免疫-炎症指数、系统性炎症反应指数和泛免疫炎症值在子痫前期预测中的作用：一项回顾性队列研究

目的：本研究旨在探讨由妊娠早期全血细胞计数（CBC）计算的全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）和泛免疫炎症值（PIV）在预测无PE和有严重特征的子痫前期（PE- sf）中的作用。方法：本回顾性队列研究纳入了2018年至2022年在一家大型三级转诊医院分娩的126名PE女性、126名PE- sf女性和126名健康、血压正常的孕妇。主要结局指标为SII、SIRI和PIV。结果：SII得分在对照组与PE组、对照组与PE- sf组之间存在显著差异，而SIRI得分在对照组与PE组、PE与PE- sf组之间存在显著差异。然而，PIV值在三组中均有显著差异。根据对SII、SIRI和PIV的区分力进行的受试者工作特征分析，预测PE的曲线下面积（AUC）分别为0.801、0.609和0.774，预测PE- sf的曲线下面积（AUC）分别为0.535、0.701和0751。截断值为> 620.59×103/µL（灵敏度81%，特异性67%）的SII和截断值为> 0.94×103/µL（灵敏度74%，特异性69%）的SIRI在预测PE和PE- sf方面分别具有最高的区分能力。结论：我们的研究结果表明，高SII、PIV和SIRI结果与未来PE风险增加之间存在关联，可以用作妊娠早期筛查试验，以改善PE预测的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.