Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES International Journal of Infectious Diseases Pub Date : 2025-02-01 DOI:10.1016/j.ijid.2024.107359

Junhong Zhou , Deshuang Xi , Yilin Teng , Shaohui Zong , Gaofeng Zeng

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Abstract

Objectives

This systematic review and meta-analysis aimed to evaluate the prevalence of bone destruction in patients with Talaromyces marneffei infection, examine distribution patterns of bone lesions, and assess differences between HIV-positive and HIV-negative patients.

Methods

Following PRISMA guidelines, 15 studies involving 839 patients were analyzed. Random-effects meta-analysis was performed to estimate prevalence and odds ratios. Study quality was assessed using ROBINS-I.

Results

The overall prevalence of bone destruction was 18% (95% CI: 10-27%). HIV-negative patients showed significantly higher odds of bone destruction (OR: 0.09, 95% CI: 0.02-0.37%). Bone lesions were widely distributed, with osseous involvement (45.7-71.4%) more prevalent than articular (7.1-66.7%). The skull, ribs, and lumbar vertebrae were commonly affected.

Conclusion

Bone destruction is a significant complication in TM infection, particularly in HIV-negative patients. The diverse anatomical distribution emphasizes the need for comprehensive skeletal assessment in suspected cases.

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马尔内菲Talaromyces marneffei感染患者骨破坏的患病率：系统回顾和荟萃分析。

目的：本系统综述和荟萃分析旨在评估马尔尼菲Talaromyces marneffei感染患者骨破坏的患病率，检查骨病变的分布模式，并评估hiv阳性和hiv阴性患者之间的差异。方法：遵循PRISMA指南，对15项研究839例患者进行分析。随机效应荟萃分析用于估计患病率和优势比。采用ROBINS-I评价研究质量。结果：骨破坏的总体发生率为18% （95% CI: 10%-27%）。hiv阴性患者骨破坏的几率明显更高（OR: 0.09, 95% CI: 0.02-0.37）。骨病变分布广泛，骨性病变（45.7-71.4%）高于关节性病变（7.1-66.7%）。颅骨、肋骨和腰椎常受影响。结论：骨破坏是TM感染的重要并发症，特别是在hiv阴性患者中。不同的解剖分布强调需要对疑似病例进行全面的骨骼评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.