Gray matter structural alterations in idiopathic rapid eye movement sleep behavior disorder: A voxel-based meta-analysis.

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY Sleep medicine Pub Date : 2024-12-04 DOI:10.1016/j.sleep.2024.12.003

Xi Wang, Yuming Li, Boyi Li, Huifang Shang, Jing Yang

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Abstract

Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a robust prodromal marker of α-synucleinopathies. Increased neuroimaging studies have explored the morphological abnormalities in iRBD, but yielded inconsistent results.

Methods: We conducted a systematic review and a voxel-wise meta-analysis of whole-brain voxel-based morphometry (VBM) studies using the anisotropic effect size version of seed-based d mapping (AES-SDM) to investigate gray matter volume (GMV) alterations in iRBD.

Results: A total of 11 studies with 12 comparisons that included 341 iRBD patients and 288 healthy controls (HCs) were identified. Patients with iRBD showed decreased GMV in the bilateral superior frontal gyri and gyrus rectus, the right temporal pole, right caudate, and right olfactory cortex, while increased GMV in the bilateral cerebellum and thalamus, and left superior occipital gyrus, relative to HCs. These findings remained largely unchanged in jackknife sensitivity analyses.

Conclusion: These abnormalities may represent the structural brain underpinnings of cognitive and sensorimotor dysfunctions in patients with iRBD and could enhance our understanding of the early signs of neurodegeneration in the prodromal stage of a-synucleinopathies.

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.