Association between retinal morphological characteristics and visual function in myopic traction maculopathy

IF 2.6 3区医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104437

Mengai Wu, Lifeng Chen, Yuanyuan Fan, Li Lin, Haidong Li, Zhijie Wang, Guanshun Yu, Xinyue Wu, Bin Zheng , Fan Lu

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Abstract

Objective

To quantify retinal morphological characteristics in patients with myopic traction maculopathy (MTM), including myopic foveoschisis (MF), using optical coherence tomography angiography (OCTA) and investigate the correlation of MTM with visual function.

Methods

This cross-sectional study included 19 eyes with myopic foveoschisis (MF) and foveal detachment (FD), 37 eyes with MF without FD, and 24 myopic eyes as control. OCTA was used to assess macular vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal avascular zone (FAZ) area, FAZ perimeter, acircularity index, retinal thickness, and retinal volume. Microperimetry was performed to evaluate macular sensitivity (MS) covering the central 20°, 10°, 2° field centered at fovea. Correlations between macular microcirculation parameters, best-corrected visual acuity (BCVA), and MS were determined.

Results

Compared to myopic controls, decreased macular parafoveal SCP VD, DCP VD, and the area VD in a 300 µm wide annulus surrounding the FAZ (FD-300), were found in the group of MF patients with FD, with (p = 0.007, 0.002, 0.005) respectively, and in the group of MF patients without FD, with (p = 0.01, 0.049, 0.009), respectively. In the MF without FD group, parafoveal SCP VD significantly correlated with BCVA, 2°MS, 10°MS, and 20°MS (p = 0.018, 0.002, 0.001, 0.029), FD-300 area density, retinal thickness, and retinal volume was significantly correlated with BCVA (p = 0.024, 0.015, 0.045). In the MF with FD group, DCP VD was significantly associated with 10° and 20° MS (p = 0.048, 0.014), as were retinal thickness and volume (all p < 0.05); however, FD-300 area density correlated significantly with BCVA (p = 0.014).

Conclusions

Macular perfusion is closely associated with functional alterations in MTM. Macular VD could serve as a valuable biomarker for monitoring MTM progression and optimizing medical and surgical decisions.

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近视牵引性黄斑病变视网膜形态特征与视功能的关系。

目的使用光学相干断层血管成像（OCTA）量化近视牵引性黄斑病变（MTM）患者（包括近视性眼窝裂（MF））的视网膜形态特征，并研究MTM与视功能的相关性：这项横断面研究包括 19 只患有近视性眼窝裂开（MF）和眼窝脱离（FD）的眼睛、37 只患有近视性眼窝裂开但没有眼窝脱离的眼睛以及 24 只近视眼作为对照。OCTA 用于评估黄斑毛细血管浅丛（SCP）、毛细血管深丛（DCP）的血管密度（VD）、眼窝无血管区（FAZ）面积、FAZ 周长、弧度指数、视网膜厚度和视网膜体积。显微视力测定法用于评估黄斑灵敏度（MS），覆盖以眼窝为中心的20°、10°和2°中央区域。确定了黄斑微循环参数、最佳矫正视力（BCVA）和黄斑灵敏度之间的相关性：与近视对照组相比，有FD的MF患者组和无FD的MF患者组的黄斑旁SCP VD、DCP VD和围绕FAZ的300微米宽环形区域（FD-300）的VD分别下降（p=0.007、0.002、0.005）和（p=0.01、0.049、0.009）。在无 FD 的 MF 组中，眼底旁 SCP VD 与 BCVA、2°MS、10°MS 和 20°MS 显著相关（p=0.018、0.002、0.001、0.029），FD-300 面积密度、视网膜厚度和视网膜体积与 BCVA 显著相关（p=0.024、0.015、0.045）。在伴有 FD 的 MF 组中，DCP VD 与 10° 和 20° MS 显著相关（p=0.048、0.014），视网膜厚度和体积也是如此（所有 p 结论：黄斑灌注与 MTM 的功能性改变密切相关。黄斑VD可作为监测MTM进展和优化医疗与手术决策的重要生物标志物。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.