From clinical to biological definitions of neurological diseases

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Medicine Pub Date : 2024-12-13 DOI:10.1038/s41591-024-03387-8

Karen O’Leary

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从神经系统疾病的临床定义到生物学定义

2月，阿尔茨海默病协会工作组发布了阿尔茨海默病（AD）诊断和分期的修订标准，以配合最近的科学进展，包括批准针对AD病理的治疗方法，以及开发可靠和可获取的生物标志物。新标准定义了“核心”（特定于AD）和“非核心”生物流体和基于成像的生物标志物；目前的诊断依赖于淀粉样蛋白和tau蛋白的存在，仅凭痴呆的临床诊断不足以诊断AD。尽管这些新标准并非没有争议，但它们已被临床学会广泛接受，并反映出神经系统疾病的生物学定义超越了阿尔茨海默病。事实上，今年发表的两个框架概述了帕金森病分期的生物学标准——尽管与阿尔茨海默病不同，这些框架尚未被广泛接受或准备用于临床。总的来说，这种神经系统疾病的生物学重构应该更好地解决研究和临床护理的优先事项。原始参考文献：阿尔茨海默病，20,5143 - 5169 (2024)；中华医学杂志，2011 (2)；柳叶刀23,191-204 (2024)；柳叶刀，23,178-190 （2024）

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

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