Chemically modified chitosan as a functional biomaterial for drug delivery system.

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Carbohydrate Research Pub Date : 2024-12-06 DOI:10.1016/j.carres.2024.109351

Devika Sajeev, Aparna Rajesh, R Nethish Kumaar, D Aswin, Rangasamy Jayakumar, Sreeja C Nair

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Abstract

Chitosan is a natural polymer that can degrade in the environment and support green chemistry. It displays superior biocompatibility, easy access, and easy modification due to the reactive amino groups to transform or improve the physical and chemical properties. Chitosan can be chemically modified to enhance its properties, such as water solubility and biological activity. Modified chitosan is the most effective functional biomaterial that can be used to deliver the drugs to the targeted site. With diverse and versatile characteristics, it can be fabricated into various drug delivery systems such as membranes, beads, fibers, microparticles, composites, and scaffolds, for different drug delivery methods. Integrating nanotechnology with modified chitosan enhanced the delivery attributes of antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, protein/peptides, and nucleic acids for intended use toward desired therapeutic outcomes. The review brings out an overview of the research regarding drug delivery systems utilizing modifying chitosan detailing the properties, functionality, and applications.

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化学修饰壳聚糖作为药物输送系统的功能性生物材料。

壳聚糖是一种天然聚合物，可在环境中降解，支持绿色化学。壳聚糖具有优越的生物相容性，易于获取，并且由于具有活性氨基，易于改性以改变或改善其物理和化学性质。壳聚糖可以通过化学改性来增强其特性，如水溶性和生物活性。改性壳聚糖是最有效的功能性生物材料，可用于将药物输送到目标部位。改性壳聚糖具有多种多样的特性，可被制成各种给药系统，如膜、珠、纤维、微颗粒、复合材料和支架，用于不同的给药方法。将纳米技术与改性壳聚糖相结合，可增强抗菌、抗真菌、抗病毒、抗癌、抗炎、蛋白质/肽和核酸的给药特性，从而达到预期的治疗效果。这篇综述概述了利用改性壳聚糖给药系统的研究，详细介绍了其特性、功能和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".