Trends and Challenges of the Modern Pathology Laboratory for Biopharmaceutical Research Excellence.

IF 1.4 4区 医学 Q3 PATHOLOGY Toxicologic Pathology Pub Date : 2024-12-13 DOI:10.1177/01926233241303898
Sílvia Sisó, Anoop Murthy Kavirayani, Suzana Couto, Birgit Stierstorfer, Sunish Mohanan, Caroline Morel, Mathiew Marella, Dinesh S Bangari, Elizabeth Clark, Annette Schwartz, Vinicius Carreira
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Abstract

Pathology, a fundamental discipline that bridges basic scientific discovery to the clinic, is integral to successful drug development. Intrinsically multimodal and multidimensional, anatomic pathology continues to be empowered by advancements in molecular and digital technologies enabling the spatial tissue detection of biomolecules such as genes, transcripts, and proteins. Over the past two decades, breakthroughs in spatial molecular biology technologies and advancements in automation and digitization of laboratory processes have enabled the implementation of higher throughput assays and the generation of extensive molecular data sets from tissue sections in biopharmaceutical research and development research units. It is our goal to provide readers with some rationale, advice, and ideas to help establish a modern molecular pathology laboratory to meet the emerging needs of biopharmaceutical research. This manuscript provides (1) a high-level overview of the current state and future vision for excellence in research pathology practice and (2) shared perspectives on how to optimally leverage the expertise of discovery, toxicologic, and translational pathologists to provide effective spatial, molecular, and digital pathology data to support modern drug discovery. It captures insights from the experiences, challenges, and solutions from pathology laboratories of various biopharmaceutical organizations, including their approaches to troubleshooting and adopting new technologies.

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现代病理实验室追求卓越生物制药研究的趋势与挑战。
病理学是连接基础科学发现和临床应用的一门基础学科,是成功药物开发不可或缺的组成部分。解剖病理学本质上是多模态和多维的,分子和数字技术的进步使解剖病理学能够对生物分子(如基因、转录本和蛋白质)进行空间组织检测。在过去的二十年里,空间分子生物学技术的突破以及实验室过程自动化和数字化的进步,使得生物制药研究和开发研究单位能够实施更高通量的分析,并从组织切片中生成广泛的分子数据集。我们的目标是为读者提供一些基本原理,建议和想法,以帮助建立一个现代分子病理学实验室,以满足生物制药研究的新兴需求。本文提供了(1)对病理学研究实践的现状和未来愿景的高层次概述;(2)分享了如何最佳地利用发现、毒理学和转化病理学家的专业知识来提供有效的空间、分子和数字病理学数据来支持现代药物发现的观点。它从各种生物制药组织的病理实验室的经验、挑战和解决方案中获得见解,包括他们的故障排除和采用新技术的方法。
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来源期刊
Toxicologic Pathology
Toxicologic Pathology 医学-病理学
CiteScore
4.70
自引率
20.00%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.
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