Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials

IF 3.9 Experimental gerontology Pub Date : 2025-01-01 DOI:10.1016/j.exger.2024.112658

Farhad Gholami , Javad Mesrabadi , Mohadeseh Iranpour , Adel Donyaei

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Abstract

This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3–4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes.

Registration number

CRD42024499195.

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运动训练可改变老年人静息脑源性神经营养因子的浓度：随机对照试验的系统回顾与荟萃分析。

本系统综述结合荟萃分析研究了运动训练对老年人脑源性神经营养因子（BDNF）的影响。检索PubMed、Web of Science和Scopus的电子数据库，寻找运动训练≥4 周对老年人静息BDNF水平影响的研究。通过随机效应模型生成标准化平均差（SMD）。35个随机对照试验符合纳入标准。运动训练显著提高血浆（SMD = 0.63）和血清（SMD = 0.54）静息BDNF水平[SMD = 0.56(95 % CI 0.28 ~ 0.85)]。在运动方式方面，有氧运动（SMD = 0.48）、阻力运动（SMD = 0.76）和联合运动训练（SMD = 0.55）增加了BDNF水平。持续时间为12 周（SMD =0.65）、中度到剧烈（SMD = 0.83）和剧烈强度（SMD = 0.71）的运动训练，以及每周3-4次的频率（SMD = 0.78）对BDNF升高的影响最大。由于BDNF在神经元过程中起着重要作用，并且与大脑健康有关，因此运动训练可能有助于延缓与衰老相关的神经退行性过程。注册号：crd42024499195。

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