Yvan Butera, Leon Mutesa, Edyth Parker, Raissa Muvunyi, Esperance Umumararungu, Alisen Ayitewala, Jean Pierre Musabyimana, Alhaji Olono, Placide Sesonga, Olusola Ogunsanya, Emmanuel Kabalisa, Oluwatobi Adedokun, Nelson Gahima, Laetitia Irankunda, Chantal Mutezemariya, Richard Niyonkuru, Arlene Uwituze, Ithiel Uwizera, James Kagame, Arlette Umugwaneza, John Rwabuhihi, Fidele Umwanankabandi, Valens Mbonitegeka, Edouard Ntagwabira, Etienne Kayigi, Gerard Izuwayo, Herve Murenzi, Therese Mukankwiro, Nasson Tuyiringire, Jean Marie Vianney Uwimana, Agnes Gasengayire, Reuben Sindayiheba, Glory-Ugochi Onyeugo, Merawi Aragaw, Lenny Gitundu, Radjabu Bigirimana, Mosoka Fallah, Adaora Ejikeme, Senga Sembuche, Alice Kabanda, Jean Claude Mugisha, Emmanuel Edwar Siddig Francis, Pierre Gashema, Jerome Ndayisenga, Alexis Rugamba, Faustin Kanyabwisha, Gad Murenzi, Anise Happi, Jean Claude Semuto Ngabonziza, Misbah Gashegu, Ayman Ahmed, Noella Bigirimana, Edson Rwagasore, Muhammed Semakula, Jean Paul Rwabihama, Clarisse Musanabaganwa, Eric Seruyange, Menelas Nkeshimana, Theogene Twagirumugabe, David Turatsinze, Eric Remera, Noel Gahamanyi, Sofonias Kifle Tessema, Isabelle Mukagatare, Sabin Nsanzimana, Christian Happi, Claude Mambo Muvunyi
{"title":"Genomic and transmission dynamics of the 2024 Marburg virus outbreak in Rwanda","authors":"Yvan Butera, Leon Mutesa, Edyth Parker, Raissa Muvunyi, Esperance Umumararungu, Alisen Ayitewala, Jean Pierre Musabyimana, Alhaji Olono, Placide Sesonga, Olusola Ogunsanya, Emmanuel Kabalisa, Oluwatobi Adedokun, Nelson Gahima, Laetitia Irankunda, Chantal Mutezemariya, Richard Niyonkuru, Arlene Uwituze, Ithiel Uwizera, James Kagame, Arlette Umugwaneza, John Rwabuhihi, Fidele Umwanankabandi, Valens Mbonitegeka, Edouard Ntagwabira, Etienne Kayigi, Gerard Izuwayo, Herve Murenzi, Therese Mukankwiro, Nasson Tuyiringire, Jean Marie Vianney Uwimana, Agnes Gasengayire, Reuben Sindayiheba, Glory-Ugochi Onyeugo, Merawi Aragaw, Lenny Gitundu, Radjabu Bigirimana, Mosoka Fallah, Adaora Ejikeme, Senga Sembuche, Alice Kabanda, Jean Claude Mugisha, Emmanuel Edwar Siddig Francis, Pierre Gashema, Jerome Ndayisenga, Alexis Rugamba, Faustin Kanyabwisha, Gad Murenzi, Anise Happi, Jean Claude Semuto Ngabonziza, Misbah Gashegu, Ayman Ahmed, Noella Bigirimana, Edson Rwagasore, Muhammed Semakula, Jean Paul Rwabihama, Clarisse Musanabaganwa, Eric Seruyange, Menelas Nkeshimana, Theogene Twagirumugabe, David Turatsinze, Eric Remera, Noel Gahamanyi, Sofonias Kifle Tessema, Isabelle Mukagatare, Sabin Nsanzimana, Christian Happi, Claude Mambo Muvunyi","doi":"10.1038/s41591-024-03459-9","DOIUrl":null,"url":null,"abstract":"The ongoing outbreak of Marburg virus disease in Rwanda marks the third largest historically, although it has shown the lowest fatality rate. Genomic analysis of samples from 18 cases identified a lineage with limited internal diversity, closely related to a 2014 Ugandan case. Our findings suggest that the Rwandan lineage diverged decades ago from a common ancestor shared with diversity sampled from bats in Uganda. Our genomic data reveal limited genetic variation, consistent with a single zoonotic transmission event and limited human-to-human transmission. Investigations including contact tracing, clinical assessments, sequencing and serology, linked the index case to a mining cave inhabited by Rousettus aegyptiacus. Serology tests identified three individuals seropositive for immunoglobulin G and immunoglobulin M, further supporting the zoonotic origin of the outbreak through human–animal interactions. Genomic analyses from the ongoing outbreak of Marburg virus disease in Rwanda point to a single zoonotic origin for the outbreak.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"31 2","pages":"422-426"},"PeriodicalIF":50.0000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41591-024-03459-9.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41591-024-03459-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The ongoing outbreak of Marburg virus disease in Rwanda marks the third largest historically, although it has shown the lowest fatality rate. Genomic analysis of samples from 18 cases identified a lineage with limited internal diversity, closely related to a 2014 Ugandan case. Our findings suggest that the Rwandan lineage diverged decades ago from a common ancestor shared with diversity sampled from bats in Uganda. Our genomic data reveal limited genetic variation, consistent with a single zoonotic transmission event and limited human-to-human transmission. Investigations including contact tracing, clinical assessments, sequencing and serology, linked the index case to a mining cave inhabited by Rousettus aegyptiacus. Serology tests identified three individuals seropositive for immunoglobulin G and immunoglobulin M, further supporting the zoonotic origin of the outbreak through human–animal interactions. Genomic analyses from the ongoing outbreak of Marburg virus disease in Rwanda point to a single zoonotic origin for the outbreak.
期刊介绍：
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
Nature Medicine consider all types of clinical research, including:
-Case-reports and small case series
-Clinical trials, whether phase 1, 2, 3 or 4
-Observational studies
-Meta-analyses
-Biomarker studies
-Public and global health studies
Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
