Autophagy modulators in type 2 diabetes: A new perspective

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-12-16 DOI:10.1111/1753-0407.70010
Ayah Talal Zaidalkilani, Hayder M. Al-kuraishy, Esraa H. Fahad, Ali I. Al-Gareeb, Yaser Hosny Ali Elewa, Mahmoud Hosny Zahran, Athanasios Alexiou, Marios Papadakis, Ammar AL-Farga, Gaber El-Saber Batiha
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Abstract

Type 2 diabetes (T2D) is a chronic metabolic disorder caused by defective insulin signaling, insulin resistance, and impairment of insulin secretion. Autophagy is a conserved lysosomal-dependent catabolic cellular pathway involved in the pathogenesis of T2D and its complications. Basal autophagy regulates pancreatic β-cell function by enhancing insulin release and peripheral insulin sensitivity. Therefore, defective autophagy is associated with impairment of pancreatic β-cell function and the development of insulin rersistance (IR). However, over-activated autophagy increases apoptosis of pancreatic β-cells leading to pancreatic β-cell dysfunction. Hence, autophagy plays a double-edged sword role in T2D. Therefore, the use of autophagy modulators including inhibitors and activators may affect the pathogenesis of T2D. Hence, this review aims to clarify the potential role of autophagy inhibitors and activators in T2D.

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2 型糖尿病(T2D)是一种由胰岛素信号缺陷、胰岛素抵抗和胰岛素分泌障碍引起的慢性代谢紊乱。自噬是一种保守的溶酶体依赖性分解代谢细胞途径,参与了 2 型糖尿病及其并发症的发病机制。基础自噬通过增强胰岛素释放和外周胰岛素敏感性来调节胰岛β细胞功能。因此,自噬缺陷与胰岛β细胞功能受损和胰岛素抵抗(IR)的发生有关。然而,过度激活的自噬会增加胰岛β细胞的凋亡,导致胰岛β细胞功能障碍。因此,自噬在 T2D 中扮演着双刃剑的角色。因此,自噬调节剂(包括抑制剂和激活剂)的使用可能会影响 T2D 的发病机制。因此,本综述旨在阐明自噬抑制剂和激活剂在 T2D 中的潜在作用。
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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
期刊最新文献
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