{"title":"Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.","authors":"Qinyan Shen, Liangying Zhao, Minjun Lu","doi":"10.62347/WJIQ1560","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.</p><p><strong>Methods: </strong>A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.</p><p><strong>Results: </strong>Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.</p><p><strong>Conclusions: </strong>Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"16 11","pages":"6467-6476"},"PeriodicalIF":1.7000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645606/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/WJIQ1560","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.
Methods: A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.
Results: Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.
Conclusions: Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.
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