Harmonic activity of glutamate dehydrogenase and neuroplasticity: The impact on aging, cognitive dysfunction, and neurodegeneration.

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2024-12-13 DOI:10.1016/j.bbr.2024.115399
Shakiba Salarvandian, Hadi Digaleh, Fariba Khodagholi, Pegah Javadpour, Sareh Asadi, Amir Ali Orang Zaman, Leila Dargahi
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Abstract

In recent years, glutamate has attracted significant attention for its roles in various brain processes. However, one of its key regulators, glutamate dehydrogenase (GDH), remains understudied despite its pivotal role in several biochemical pathways. Dysfunction or dysregulation of GDH has been implicated in aging and various neurological disorders, such as Alzheimer's disease and Parkinson's disease. In this review, the impact of GDH on aging, cognitive impairment, and neurodegenerative conditions, as exemplars of the phenomena that may affected by neuroplasticity, has been reviewed. Despite extensive research on synaptic plasticity, the precise influence of GDH on brain structure and function remains undiscovered. This review of existing literature on GDH and neuroplasticity reveals diverse and occasionally conflicting effects. Future research endeavors should aim to describe the precise mechanisms by which GDH influences neuroplasticity (eg. synaptic plasticity and neurogenesis), particularly in the context of human aging and disease progression. Studies on GDH activity have been limited by factors such as insufficient sample sizes and varying experimental conditions. Researchers should focus on investigating the molecular mechanisms by which GDH modulates neuroplasticity, utilizing various animal strains and species, ages, sexes, GDH isoforms, brain regions, and cell types. Understanding GDH's role in neuroplasticity may offer innovative therapeutic strategies for neurodegenerative and psychiatric diseases, potentially slowing the aging process and promoting brain regeneration.

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谷氨酸脱氢酶的谐调活性与神经可塑性:对衰老、认知功能障碍和神经变性的影响。
近年来,谷氨酸因其在各种大脑过程中的作用而备受关注。然而,尽管谷氨酸脱氢酶(GDH)在几种生化途径中发挥着关键作用,但其关键调控因子之一的谷氨酸脱氢酶(GDH)仍未得到充分研究。GDH 的功能障碍或失调与衰老和各种神经系统疾病(如阿尔茨海默病和帕金森病)有关。在这篇综述中,我们回顾了 GDH 对衰老、认知障碍和神经退行性疾病的影响,并举例说明了可能受神经可塑性影响的现象。尽管对突触可塑性进行了广泛的研究,但 GDH 对大脑结构和功能的确切影响仍未被发现。这篇关于 GDH 和神经可塑性的现有文献综述揭示了各种不同的影响,有时甚至是相互矛盾的影响。未来的研究应致力于描述 GDH 影响神经可塑性(如突触可塑性和神经发生)的确切机制,尤其是在人类衰老和疾病进展的背景下。有关 GDH 活性的研究受到样本量不足和实验条件不同等因素的限制。研究人员应利用不同的动物品系和物种、年龄、性别、GDH 同工型、大脑区域和细胞类型,重点研究 GDH 调节神经可塑性的分子机制。了解 GDH 在神经可塑性中的作用可为神经退行性疾病和精神疾病提供创新的治疗策略,从而有可能减缓衰老过程并促进大脑再生。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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