{"title":"The safety and efficacy of applying a high-current temporal interference electrical stimulation in humans.","authors":"Yan Wang, Ginger Qinghong Zeng, Mengmeng Wang, Mingsong Zhang, Chuangchuang Chang, Qiongwei Liu, Keqing Wang, Ru Ma, Ying Wang, Xiaochu Zhang","doi":"10.3389/fnhum.2024.1484593","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Temporal interference electrical stimulation (TI) is promise in targeting deep brain regions focally. However, limited electric field intensity challenges its efficacy.</p><p><strong>Objective: </strong>This study aimed to introduce a high-current TI electrical stimulation protocol to enhance its intensity and evaluate its safety and efficacy when applied to the primary motor cortex (M1) in the human brain.</p><p><strong>Methods: </strong>Safety assessments included a battery of biochemical and neuropsychological tests (NSE, MoCA, PPT, VAMS-R, and SAS measurements), 5-min resting-state electroencephalography (EEG) recordings before and after 30-min high-current TI electrical stimulation sessions (20 Hz, 70 Hz, sham). Adverse reactions were also documented post-stimulation. Efficacy evaluations involved two motor tasks, the simple reaction time (SRT) task and the one-increment task, to investigate the distinct contributions of beta (20 Hz) and gamma (70 Hz) oscillations to motor functions.</p><p><strong>Results: </strong>Biochemical and neuropsychological tests revealed no significant differences between the groups. Additionally, no epileptic activities were detected in the EEG recordings. In the one-increment task, 20 Hz stimulation delayed participants' reaction time compared to the 70 Hz and sham groups. Conversely, in the SRT task, 70 Hz stimulation exhibited a tendency to enhance participants' performance relative to the sham group.</p><p><strong>Conclusion: </strong>The proposed high-current TI electrical stimulation is both safe and effective for stimulating the human brain. Moreover, the distinct effects observed in motor tasks underscore the dissociative roles of beta and gamma oscillations in motor functions, offering valuable insights into the potential applications of high-current TI electrical stimulation in brain stimulation research.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1484593"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638170/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Human Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnhum.2024.1484593","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Temporal interference electrical stimulation (TI) is promise in targeting deep brain regions focally. However, limited electric field intensity challenges its efficacy.
Objective: This study aimed to introduce a high-current TI electrical stimulation protocol to enhance its intensity and evaluate its safety and efficacy when applied to the primary motor cortex (M1) in the human brain.
Methods: Safety assessments included a battery of biochemical and neuropsychological tests (NSE, MoCA, PPT, VAMS-R, and SAS measurements), 5-min resting-state electroencephalography (EEG) recordings before and after 30-min high-current TI electrical stimulation sessions (20 Hz, 70 Hz, sham). Adverse reactions were also documented post-stimulation. Efficacy evaluations involved two motor tasks, the simple reaction time (SRT) task and the one-increment task, to investigate the distinct contributions of beta (20 Hz) and gamma (70 Hz) oscillations to motor functions.
Results: Biochemical and neuropsychological tests revealed no significant differences between the groups. Additionally, no epileptic activities were detected in the EEG recordings. In the one-increment task, 20 Hz stimulation delayed participants' reaction time compared to the 70 Hz and sham groups. Conversely, in the SRT task, 70 Hz stimulation exhibited a tendency to enhance participants' performance relative to the sham group.
Conclusion: The proposed high-current TI electrical stimulation is both safe and effective for stimulating the human brain. Moreover, the distinct effects observed in motor tasks underscore the dissociative roles of beta and gamma oscillations in motor functions, offering valuable insights into the potential applications of high-current TI electrical stimulation in brain stimulation research.
期刊介绍：
Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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